Metabolism and energy
Cathelicidin carbamylation
Chemical modification of cathelicidin peptides by cyanate that can change their antimicrobial activity, cell recruitment and cytotoxicity
Hypotheses on this target 1
Inhibition1
Activation
Function preservation
Supplementation
Feedback restoration
Direct measurement
Inhibition1
Carbamylation may turn protective cathelicidins into tissue-damaging molecules
Where this hypothesis actsCathelicidins released by myeloid cells into tissue with increased cyanate formation
What is proposedLimit carbamylation that produces tissue-damaging cathelicidin forms
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible reduction in tissue damage while retaining antimicrobial protection
2026-09-30