Live·Open questions in longevity research
All targets

Signalling pathway

cGAS–STING signaling

An immune signaling pathway through which intracellular DNA signals are classified as damage signals

Hypotheses on this target 1

cGAS–STING signalingInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Desensitisation
  • Function preservation
  • Feedback restoration
  • Rhythm restoration

Inhibition1

  • Mistaking background genetic signals for damage may keep skin defending instead of repairing

    Where this hypothesis actsSkin of 50-year-olds, with background intracellular DNA signals misclassified as ongoing damage

    What is proposedSelectively suppress background signaling that incorrectly indicates ongoing damage

    With whatNot stated in the record

    HowNot stated in the record; suppression must preserve the response to an independent validated immune challenge

    Possible resultPossible restoration of tissue function despite retained aged mechanics and senescent cell burden

    2026-09-29