Mechanics and load
Calcium phosphate mineral growth
The growth of calcium phosphate mineral in particles within the extracellular environment
Hypotheses on this target 4
Inhibition3
Activation
Function preservation
Remodelling
Load normalisation
Direct measurement
Inhibition3
Calcium phosphate particle growth may sustain damage between the gut and blood vessels
Where this hypothesis actsMetastable extracellular conditions during ageing, linking vascular damage and impaired intestinal repair
What is proposedTemporarily suppress mineral growth to interrupt continued particle formation
With whatNot stated in the record
HowInhibit mineral growth in one causal link and remove remaining crystallization centres; selectively dissolve the mineral phase of the returned fraction
Possible resultPossible sustained interruption of particle formation and the resulting cycle of tissue damage
2026-09-30
Calcium phosphate seeds may accumulate under repeated loads and impair skin shape recovery
Where this hypothesis actsIn the dermis during repeated mechanical loading with transient local mineral supersaturation
What is proposedSuppress crystal growth and prevent the formation of persistent mineral nuclei
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible stabilization of SPV_3 under repeated loading and reduced dependence of mechanical defects on load order
2026-09-25
Mineral deposits make expanded skin matrix brittle after filler resorption
Where this hypothesis actsNew collagen and adjacent damaged elastic fibers in susceptible photoaged skin after matrix expansion
What is proposedPrevent mineral nucleation and reduce established mineral deposits
With whatNot stated in the record
HowSelective demineralization in paired excised samples; prevention tested in living constructs, with no prevention method specified. Not proposed as a human treatment
Possible resultPossible preservation of wound maturation and improved cyclic fatigue resistance after filler resorption
2026-09-21