Live·Open questions in longevity research
All targets

Immune cell

Group 3 innate lymphoid cells

A population of innate lymphoid cells that can release interleukin-22

Hypotheses on this target 1

Group 3 innate lymphoid cellsActivation. Hypotheses on this target 11Clearance restoration. Hypotheses on this target 0Reprogramming. Hypotheses on this target 0Adoptive transfer. Hypotheses on this target 0Elimination. Hypotheses on this target 0Immunosuppression. Hypotheses on this target 0Population balance. Hypotheses on this target 0
  • Activation1
  • Clearance restoration
  • Reprogramming
  • Adoptive transfer
  • Elimination
  • Immunosuppression
  • Population balance

Activation1

  • Mimicking gut glial signals may extend life through lymphoid and epithelial protection

    Where this hypothesis actsRET-positive cells in the intestinal mucosa exposed to a local GDNF pulse

    What is proposedStimulate interleukin-22 release

    With whatProtein or peptide as the agent

    HowDeliver a short, local pulse of GDNF with the required GFRα1 coreceptor available to activate RET

    Possible resultPossible epithelial protection against repeated microbial injury and consequent lifespan extension

    2026-10-05