Live·Open questions in longevity research
All targets

Enzyme

CAD

Caspase-activated DNase, an enzyme that cleaves DNA

Hypotheses on this target 1

CADInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 11Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation1
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Activation1

  • Brief breaks in genetic material may complete intestinal cell maturation and curb harmful growth

    Where this hypothesis actsMaturing intestinal epithelial cells after barrier restoration

    What is proposedBriefly activate CAD to promote stable differentiation

    With whatNot stated in the record

    HowA temporarily inducible CAD activation system producing brief, localized DNA cleavage, followed by precise repair

    Possible resultPossible stable differentiation, reduced pathological clonal expansion and lower tumour mortality

    2026-10-05