Immune cell
Macrophages
Immune cells that can undergo M2 polarization and secrete TGF-β1
Hypotheses on this target 2
Activation
Clearance restoration
Reprogramming2
Adoptive transfer
Elimination
Immunosuppression
Population balance
Reprogramming2
The link between resolving inflammation and fibrosis is an artefact of culture plastic
Where this hypothesis actsHuman monocyte-derived macrophages cultured on 2 kPa polyacrylamide gels or tissue culture plastic
What is proposedInduce M2 polarization
With whatSmall molecule
HowPolarize macrophages with resolvin D1 and compare TGF-β1 secretion on compliant gels and tissue culture plastic
Possible resultExpected TGF-β1 increase below twofold on compliant gels but above fivefold on plastic
2026-09-14
Ageing installs the anti-fibrotic switch that spiny mice are born with
Where this hypothesis actsHuman niche macrophages from aged and young donors, tested ex vivo
What is proposedInduce M2 polarization with SPM stimulation
With whatSmall molecule
HowEx vivo SPM polarization assays with TGF-β1 secretion measured by ELISA
Possible resultExpected absence of increased TGF-β1 secretion in aged macrophages despite SPM-driven M2 polarization
2026-09-14