Stem cell
Basal cells
Cells whose populations can persist through self-renewal or decline through cell death and differentiation
Hypotheses on this target 1
Reprogramming
Transplantation
Directed differentiation
Proliferation
Population balance1
Population balance1
Repeated treatment may select resistant cell lineages that cross a threshold for sustained growth
Where this hypothesis actsDrug-resistant lineages surviving repeated antimetabolite courses in skin, after treatment withdrawal
What is proposedLimit persistence of lineages whose basal cell production exceeds cell loss
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible stabilization of the treatment-associated component of SPV_11
2026-09-25