Live·Open questions in longevity research
All targets

Rhythm or programme

Paracrine signal–response synchrony

Temporal overlap between the availability of a locally released signal and the receiving cells' ability to respond

Hypotheses on this target 1

Paracrine signal–response synchronyInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 11Direct measurement. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Function preservation
  • Feedback restoration
  • Rhythm restoration1
  • Direct measurement

Rhythm restoration1

  • Timed interleukin-1 and keratinocyte growth factor signaling may restore skin readiness

    Where this hypothesis actsReciprocal interleukin-1 and FGF7 signalling between epidermal keratinocytes and dermal fibroblasts

    What is proposedRestore overlap between signal availability and recipient cell responsiveness

    With whatChange of environment or regimen

    HowShift equal-dose FGF7 pulses into epidermal sensitivity windows; shift interleukin-1 pulses into fibroblast sensitivity windows when that step limits recovery

    Possible resultPossible shortening of the vulnerability period and stabilization of SPV_4 after repeated stress

    2026-09-25