Immune response
Inflammation resolution
The process through which inflammation comes to an end
Hypotheses on this target 4
Inhibition1
Activation1
Function preservation
Clearance restoration
Immunosuppression
Feedback restoration1
Rhythm restoration1
Inhibition1
Longer inflammation may speed healing by damaging both strands of bacterial genetic material
Where this hypothesis actsIn a skin model containing viable microorganisms, with microbial burden and matrix maturity controlled
What is proposedDelay the completion of inflammation
With whatNot stated in the record
HowExtend oxidative exposure to promote spatially coincident damage to both bacterial DNA strands; the intervention used to delay resolution is not stated
Possible resultPossible shorter functional healing time through prevention of renewed bacterial growth and recurrent inflammation
2026-09-25
Activation1
Conflating immune suppression with active resolution may explain an apparent benefit of delay
Where this hypothesis actsDuring skin healing in immunocompetent models
What is proposedInitiate active resolution early while preserving microbial control
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible equal or shorter time to recovery of barrier function, load resistance and microbial control
2026-09-25
Feedback restoration1
Delayed feedback causes microbial and inflammatory rebound during skin repair
Where this hypothesis actsSkin wounds during overlapping mild injuries
What is proposedAdjust clearance-triggered resolution timing and feedback gain to restore stable responses
With whatPhysical or surgical intervention
HowUse an automated controller with spatial microbial and inflammatory sampling to shorten sensing-to-response delay, compensate for delay or lower feedback gain
Possible resultPossible prevention of microbial and inflammatory rebound without sacrificing differentiation
2026-09-21
Rhythm restoration1
Accelerated inflammation resolution removes living defenders and weakens infection control
Where this hypothesis actsAt the graft interface when shifted sleep and feeding align macrophage engulfment with neutrophil activation
What is proposedTime resolution support outside the overlap of engulfment and neutrophil activation
With whatChange of environment or regimen
HowProvide resolution support outside the phase when heightened macrophage engulfment coincides with peak neutrophil activation
Possible resultPossible preservation of both pathogen containment and graft function
2026-09-20