Indicator or biomarker
mt-Keima signal
A mitochondrial reporter signal that changes with lysosomal acidity and the amount of accumulated reporter
Hypotheses on this target 1
Telling states apart1
Direct measurement
Indicator replacement
Telling states apart1
Lysosomal acidity may mimic faster mitochondrial removal
Where this hypothesis actsAfter mTOR suppression, with mitochondrial reporter already accumulated in lysosomes
What is proposedCalibrate the signal to distinguish acidity effects from mitochondrial clearance
With whatInstrument or assay
HowMeasure acidity and accumulated reporter independently, then compare with independent tracking of labelled mitochondrial delivery and destruction
Possible resultExpected disappearance of the apparent increase in mitophagy after calibration
2026-09-30