Live·Open questions in longevity research
All targets

Receptor or channel

TRPV4

A protein involved in the formation and restoration of junctions between keratinocytes

Hypotheses on this target 1

TRPV4Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 11Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade1
  • Agonism
  • Desensitisation
  • Function restoration
  • Function preservation

Blockade1

  • Blocking junction repair may align defects across skin layers and increase penetration

    Where this hypothesis actsKeratinocytes after wet friction, after the first protective response but before junction repair is complete

    What is proposedDelay TRPV4 inhibition until after the first protective response

    With whatControlled genetic model

    HowDelayed TRPV4 blockade before junction repair is complete, with keratinocyte-specific TRPV4 inactivation as a comparison

    Possible resultExpected increase in vertically aligned barrier defects and tracer penetration compared with IL-31 blockade

    2026-09-25