Signalling molecule
CGRP
Calcitonin gene-related peptide, a signal released by sensory nerve endings
Hypotheses on this target 2
Lower level
Synthesis suppression
Neutralisation
Supplementation2
Accelerated excretion
Supplementation2
A microbial protease may limit skin inflammation through a nerve-to-immune signal
Where this hypothesis actsLocal signalling between sensory nerve endings and immune cells in ageing skin
What is proposedRestore local CGRP signalling
With whatNot stated in the record
HowLocal restoration of the CGRP signal; the delivery method is not stated
Possible resultPossible recovery of the protective signal despite neuronal PAR1 being switched off
2026-09-26
Repeated fractional treatment may slow skin recovery by injuring regrowing sensory axons
Where this hypothesis actsDenervated skin in a proposed preclinical experiment
What is proposedRestore CGRP signaling despite persistent denervation
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible partial recovery of barrier and repair responses, with sensory deficits remaining
2026-09-25