Live·Open questions in longevity research
All targets

Metabolism and energy

Mitochondrial fusion

The joining of mitochondria to form connected networks

Hypotheses on this target 1

Mitochondrial fusionInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 11Supplementation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0

Function preservation1

  • Connected mitochondria may protect ageing heart cells when muscle glutamine supply falls

    Where this hypothesis actsAgeing cardiomyocytes during early-fasting mimetic treatment and delayed feeding

    What is proposedBriefly preserve physiological mitochondrial fusion

    With whatNot stated in the record

    HowCombine an early-fasting signal with brief preservation of physiological mitochondrial fusion through OPA1

    Possible resultPossible preservation of cardiac function with less reliance on muscle-derived glutamine and less cardiac damage

    2026-10-06