Receptor or channel
HCMV Fc-binding proteins
Viral proteins that bind antibody Fc and obstruct its engagement with host Fc receptors
Hypotheses on this target 1
Lower level
Higher level
Blockade1
Agonism
Desensitisation
Function restoration
Function preservation
Blockade1
Viral capture of antibody tails blocks multiple routes for eliminating infected cells
Where this hypothesis actsInfected targets in older-donor tissue with adequate antibody occupancy but impaired Fc-dependent clearance
What is proposedPrevent viral proteins from capturing antibody Fc
With whatAntibody or binding reagent
HowUse Fc variants with reduced viral-receptor binding while matching antibody dose, Fab specificity, neutralization, host Fc-receptor binding and tissue occupancy
Possible resultExpected restoration of infected-target elimination and viable-burden decline without increasing antibody dose
2026-09-21