Live·Open questions in longevity research

Rhythm or programme

Horizontal nuclear DNA transfer

Acquisition of nuclear DNA from one cell by another, with fragments becoming heritable in the recipient lineage

Hypotheses on this target 1

Horizontal nuclear DNA transferInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Function preservation
  • Feedback restoration
  • Rhythm restoration
  • Direct measurement

Inhibition1

  • Repeated skin repair lets surviving cells inherit DNA from dying neighbours

    Where this hypothesis actsFrom dying keratinocytes to checkpoint-defective non-RAS keratinocytes during repeated EGFR-supported repair

    What is proposedPrevent heritable acquisition of donor nuclear DNA

    With whatNot stated in the record

    HowDegrade DNA within experimentally isolated apoptotic material before reconstitution, while preserving other corpse functions and repair

    Possible resultPossible stabilization of SPV_10 and prevention of recipient competitive gains while preserving repair

    2026-09-21