Live·Open questions in longevity research
All targets

Enzyme

LOX

Lysyl oxidase, an enzyme involved in forming extracellular matrix crosslinks

Hypotheses on this target 1

LOXInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 11Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Lower level1
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Lower level1

  • Restoring support flexibility may let intestinal progenitors complete repair and extend life

    Where this hypothesis actsPericryptal fibroblasts in the aged intestine

    What is proposedTransiently suppress LOX to limit new stiff crosslinks

    With whatRNA interference or antisense

    HowDeliver a targeted, brief pulse of small interfering RNA against LOX to pericryptal fibroblasts, followed by enzyme recovery

    Possible resultPossible restoration of matrix compliance during natural matrix turnover

    2026-10-05