Live·Open questions in longevity research

Microbial community

Gut microbiota

The community of microorganisms living in the gut

Hypotheses on this target 3

Gut microbiotaPopulation balance. Hypotheses on this target 11Community restoration. Hypotheses on this target 0Colonisation. Hypotheses on this target 11

Population balance1

  • Cyclic microbial competition may drive recurring skin damage through protease release

    Where this hypothesis actsSkin exposed to repeated applications of a drug or its vehicle, with three competing microbial strategies

    What is proposedRemove one participant to interrupt cyclic microbial competition

    With whatNot stated in the record

    HowRemove one member of the community comprising an antimicrobial producer, a resistant strain and a sensitive fast-growing strain

    Possible resultPossible interruption of repeated protease and skin damage peaks

    2026-09-25

Colonisation1

  • Sleep-first treatment may sustain recovery by changing which gut microbes establish first

    Where this hypothesis actsDuring menopause treatment, with starting communities and antibiotic exposures potentially affecting responses

    What is proposedEstablish a recovery-associated community and sustain its metabolic output

    With whatChange of environment or regimen

    HowApply sleep rehabilitation before vasomotor suppression so recovery-associated strains establish; competitive exclusion is proposed to maintain the community

    Possible resultPossible durable autonomic benefit after treatment ends

    2026-10-03