Enzyme
Acyloxyacyl hydrolase
An enzyme that deacylates bacterial lipid A, reducing its biological activity
Hypotheses on this target 1
Inhibition
Activation
Lower level
Higher level
Replacement1
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Replacement1
Active bacterial lipids left after clearance renew inflammation after injury
Where this hypothesis actsAfter verified Gram-negative microbial clearance, before a second sterile mild injury
What is proposedRestore acyloxyacyl hydrolase activity
With whatProtein or peptide as the agent
HowLocal supplementation with active enzyme or enzyme expression, compared with catalytically inactive enzyme
Possible resultPossible prevention of inflammatory recurrence and differentiation loss without prolonged phagocyte recruitment
2026-09-21