Fibroblast or stromal cell
Myofibroblasts
Cells involved in tissue repair that can undergo apoptosis as their participation in healing ends
Hypotheses on this target 1
Senomorphic suppression
Reprogramming
Transplantation
Elimination1
Population balance
Elimination1
Late Yes-associated protein activity may limit skin scarring by killing damaged repair cells
Where this hypothesis actsDamaged myofibroblasts with an uncompleted apoptosis programme after repeated injury to photodamaged skin
What is proposedInduce apoptosis in damaged myofibroblasts at the end of dermal repair
With whatNot stated in the record
HowRestore a short late YAP pulse that activates apoptosis through Tyr357 phosphorylation and binding to p73
Possible resultPossible completion of dermal repair with less residual contracture and scarring
2026-09-26