Live·Open questions in longevity research
All targets

Immune response

Complement cascade

An enzymatic cascade involved in immune responses

Hypotheses on this target 1

Complement cascadeInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Clearance restoration. Hypotheses on this target 0Immunosuppression. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Function preservation
  • Clearance restoration
  • Immunosuppression
  • Feedback restoration
  • Rhythm restoration

Inhibition1

  • Delaying neutrophil uptake may preserve vesicle-mediated complement inhibition

    Where this hypothesis actsExtracellularly during inflammation resolution after EP2 suppression

    What is proposedSustain extracellular inhibition of the complement cascade

    With whatProtein or peptide as the agent

    HowPreserve neutrophil production of CD55-positive extracellular vesicles by delaying engulfment; administer purified vesicles in the rescue experiment

    Possible resultPossible shortening of the inflammation-resolution period SPV_3 and improved multisystem recovery

    2026-09-30