Live·Open questions in longevity research
All targets

Rhythm or programme

Mitotic synchrony

The alignment in time of neighboring cells entering and undergoing division

Hypotheses on this target 1

Mitotic synchronyInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0Direct measurement. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Function preservation
  • Feedback restoration
  • Rhythm restoration
  • Direct measurement

Inhibition1

  • Repeated growth signals favor abnormal skin cell clones by crowding dividing neighbors

    Where this hypothesis actsNaturally photoaged human epidermal mosaics receiving repeated EGFR stimulation

    What is proposedDisrupt overlapping mitotic occupancy in neighboring cells

    With whatPhysical or surgical intervention

    HowSpatially stagger EGFR pulses using patterned microfluidic exposure while matching local ligand exposure, integrated receptor activation, and cumulative divisions

    Possible resultPossible prevention of non-RAS clone enrichment without reducing cumulative renewal

    2026-09-21