Enzyme
FAK
A protein involved in fibroblast contractility and its contribution to mechanical damping
Hypotheses on this target 2
Inhibition2
Activation
Lower level
Higher level
Replacement
Protection from degradation
Cofactor removal
Synthesis suppression
Function preservation
Inhibition2
Precisely timed fibroblast contraction protects aging skin during movement
Where this hypothesis actsAged full-thickness skin explants under cyclic shear, with impaired hypodermal support
What is proposedBlock FAK to test its contribution to reversible cellular damping
With whatNot stated in the record
HowNot stated in the record
Possible resultExpected loss of reversible cellular damping before structural changes, followed by strain and attachment separation
2026-09-21
Blocking a repair signal selects against matrix-building cells and weakens skin
Where this hypothesis actsSkin repair under ordinary cyclic shear when hypodermal support is impaired
What is proposedBlock FAK activity
With whatNot stated in the record
HowNot stated in the record
Possible resultExpected early contracture reduction followed by mechanical failure if the contributing fraction becomes insufficient
2026-09-21