Live·Open questions in longevity research
All targets

Physical property of tissue

Tissue compression

Physical compression arising when cells occupy limited space within a tissue

Hypotheses on this target 1

Tissue compressionRemodelling. Hypotheses on this target 0Composition restoration. Hypotheses on this target 0Load normalisation. Hypotheses on this target 11Direct measurement. Hypotheses on this target 0

Load normalisation1

  • Repeated growth signals favor abnormal skin cell clones by crowding dividing neighbors

    Where this hypothesis actsLocal crowding peaks during repeated EGFR-driven divisions in photoaged epidermal mosaics

    What is proposedReduce peak local compression

    With whatPhysical or surgical intervention

    HowMechanically increase the available area as an independent rescue intervention

    Possible resultPossible prevention of preferential normal-cell basal exit and non-RAS clone enrichment

    2026-09-21