Fibroblast or stromal cell
Mesenchymal stromal cells
Stromal cells that provide local signals supporting neighboring cell populations
Hypotheses on this target 1
Senomorphic suppression
Reprogramming
Transplantation1
Elimination
Population balance
Transplantation1
Replacing small, distributed support-cell patches in the thymus is enough to slow aging
Where this hypothesis actsFGF7/FGF10-producing thymic organizer microdomains at ages 60, 70 and 80
What is proposedReplace 10% of the baseline intrathymic mesenchymal-cell population
With whatCell therapy
HowIntroduce functionally young, compatible cells across both thymic lobes at positions selected by a morphogen-threshold coverage model; repeat at ages 70 and 80
Possible resultPossible restoration of thymopoietic support, immune renewal and protection across functional domains
2026-09-20