Rhythm or programme
Polyploidization
An increase in the number of genome copies within a cell
Hypotheses on this target 2
Inhibition2
Activation
Function preservation
Feedback restoration
Rhythm restoration
Direct measurement
Inhibition2
Repeated fractional skin injury may slow repair by doubling genomes without cell division
Where this hypothesis actsSurviving fibroblasts and some basal keratinocytes after repeated fractional injury
What is proposedPrevent repeated genome duplication without cell division
With whatNot stated in the record
HowNot stated in the record
Possible resultPossible preservation of barrier repair, mechanical recovery and innervation despite reduced collagen gain
2026-09-25
Repair-driven genome doubling preserves wound closure but disables later hair regeneration
Where this hypothesis actsActivated follicular progenitors and their niche-retained descendants during repeated repair in aged skin
What is proposedPrevent persistent genome doubling during repair
With whatNot stated in the record
HowA selective intervention remains to be developed that prevents endoreduplication without independently altering repair or tumor risk
Possible resultPossible preservation of subsequent hair output and stabilization of SPV_5 without reducing follicular export
2026-09-21