Metabolism and energy
Mitochondrial proton leak
Proton passage across the inner mitochondrial membrane that increases oxygen consumption relative to ATP production
Hypotheses on this target 1
Inhibition1
Activation
Function preservation
Supplementation
Feedback restoration
Direct measurement
Inhibition1
Mitochondrial proton leakage may make kidney transport consume oxygen inefficiently
Where this hypothesis actsMitochondria of vulnerable downstream renal tubular cells after SGLT2 blockade
What is proposedReduce excess proton leak to restore coupling of respiration and ATP synthesis
With whatNot stated in the record
HowCorrect the molecular source of the leak after identifying it, while preserving distal reabsorption; the specific intervention is not stated
Possible resultPossible restoration of tissue oxygenation and reserve, stabilization of SPV_9 and reduced renal contribution to decline
2026-09-30