Way of recording
Contractile exit assessment
Assessment of contraction resolution, tissue mobility, senescence, and proliferative persistence
Hypotheses on this target 1
Telling states apart1
Direct measurement
Indicator replacement
Telling states apart1
Different outcomes explain the apparent reversal of Yes-associated protein's effects
Where this hypothesis actsPost-closure fibroblasts under matched YAP perturbations and different matrix tensions
What is proposedDistinguish molecular marker changes from durable functional contractile exit
With whatInstrument or assay
HowMeasure force, recoil, appendage displacement, senescence, and proliferative persistence in the same specimens after withdrawal; separate active contraction from passive stiffness
Possible resultExpected marker benefits without a tension-dependent reversal in YAP effects on active traction and durable mobility
2026-09-21