Specialised cell of an organ
Corticotrophs
Cells of the anterior pituitary involved in glucocorticoid feedback regulation
Hypotheses on this target 1
Function restoration1
Reprogramming
Transplantation
Elimination
Proliferation
Function restoration1
Joint pituitary and adrenal correction may restore hormone pulses and improve multiple functions
Where this hypothesis actsAnterior pituitary in old mice with defects in both pituitary feedback and adrenal response timing
What is proposedRestore glucocorticoid feedback sensitivity in 50% of corticotrophs
With whatControlled genetic model
HowInducible tissue-specific genetic systems, with corrected cells distributed across the tissue; the required fraction needs calibration
Possible resultPossible restoration of corticosterone pulses and three functional trajectories when both populations are corrected
2026-09-30