Live·Open questions in longevity research
All targets

Immune response

Extracellular vesicle clearance

The uptake and removal of extracellular vesicles

Hypotheses on this target 1

Extracellular vesicle clearanceInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Clearance restoration. Hypotheses on this target 11Immunosuppression. Hypotheses on this target 0Feedback restoration. Hypotheses on this target 0Rhythm restoration. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Function preservation
  • Clearance restoration1
  • Immunosuppression
  • Feedback restoration
  • Rhythm restoration

Clearance restoration1

  • Vesicle removal may limit damage from elastase shielded against its natural inhibitor

    Where this hypothesis actsMacrophage uptake of neutrophil vesicles carrying active elastase while whole-neutrophil engulfment is blocked

    What is proposedRestore clearance of elastase-bearing extracellular vesicles

    With whatNot stated in the record

    HowSuppress EP2 to restore macrophage uptake of these vesicles while maintaining blockade of whole-neutrophil engulfment

    Possible resultPossible reduction in residual functional deficit SPV_6 through removal of protease carriers

    2026-09-30