Metabolism and energy
Autophagy
The cellular process of breaking down and recycling damaged components
Hypotheses on this target 2
Inhibition
Activation1
Function preservation1
Supplementation
Feedback restoration
Direct measurement
Activation1
Altered cells may suppress normal repair through an enzyme above a local abundance threshold
Where this hypothesis actsNormal cells exposed to the mimetic alongside altered cells
What is proposedStimulate autophagy while limiting NOTUM-mediated competition
With whatSmall molecule
HowUse an autophagy mimetic together with time-limited NOTUM suppression
Possible resultPossible retention of the normal-cell autophagic response without the threshold-dependent clonal advantage
2026-10-06
Function preservation1
Different protein lifetimes may separate spermidine-driven cell recycling from clonal growth
Where this hypothesis actsIntestinal organoids after a short spermidine-mimetic pulse and during feeding resumption
What is proposedSustain elevated autophagic flux through the resumption of feeding
With whatSmall molecule
HowApply a short spermidine-mimetic pulse and resume feeding while the TFEB-induced lysosomal machinery remains functional after additional MYC activity subsides
Possible resultPossible continued recycling of damaged components and functional benefit with less growth of altered cells
2026-10-06