Signalling pathway
Antigen-receptor signaling
Signaling through antigen receptors during cognate antigen recognition
Hypotheses on this target 3
Inhibition1
Activation
Desensitisation
Function preservation
Feedback restoration
Rhythm restoration1
Inhibition1
Exposure order blocks unfamiliar immune cells through receptor-specific inhibitory signals
Where this hypothesis actsUnfamiliar T cells during their founding activation window in the presence of familiar peptide–MHC ligands
What is proposedSuppress antagonistic TCR signaling while preserving productive recall stimulation
With whatProtein or peptide as the agent
HowSubstitute familiar peptides with variants outside the unfamiliar TCR's mapped antagonist region while retaining equivalent recall stimulation
Possible resultPossible abolition of the order-dependent persistence deficit in unfamiliar T-cell clones
2026-09-21
Rhythm restoration1
Incoming immune cells disrupt resident cells’ antiviral signaling through long pauses
Where this hypothesis actsProtective tissue residents encountering sparse antigen at latent-virus reservoirs during successor recruitment
What is proposedRestore temporal reliability and reduce prolonged gaps in productive signaling
With whatNot stated in the record
HowMake inhibitory contacts less intermittent while retaining their integrated magnitude and matching mean signaling in a calibrated ex vivo system
Possible resultPossible improvement in local viral control through fewer long signaling gaps
2026-09-21