Live·Open questions in longevity research
All targets

Structural protein

Collagen VII

A structural collagen forming anchoring fibrils that transmit external loads to cells

Hypotheses on this target 1

Collagen VIILower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Function preservation. Hypotheses on this target 0Remodelling. Hypotheses on this target 11Crosslink prevention. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Function preservation
  • Remodelling1
  • Crosslink prevention

Remodelling1

  • Restored skin anchors may trigger cell contraction that reopens healed wounds

    Where this hypothesis actsAnchoring fibrils in aged skin after wound closure, tested alongside PIEZO1 suppression

    What is proposedRestore mature collagen VII anchoring fibrils to the young range

    With whatNot stated in the record

    HowNot stated in the record

    Possible resultPossible unchanged or reduced shear tolerance with active PIEZO1 because restored fibrils transmit load more effectively

    2026-09-26