Signalling molecule
Extracellular histones
Histone proteins outside cells that can cause membrane injury
Hypotheses on this target 1
Lower level
Synthesis suppression
Neutralisation1
Supplementation
Accelerated excretion
Neutralisation1
Living replacement cells can sustain tissue injury by releasing toxic histones
Where this hypothesis actsReleased by viable replacement parenchymal cells after a transient clearance deficit
What is proposedNeutralize replacement-derived extracellular histones
With whatNot stated in the record
HowSelective extracellular neutralization while preserving graft viability, proliferation, geometry, and mechanical confinement
Possible resultPossible termination of the injury–secretion loop and restoration of histone clearance
2026-09-20