Live·Open questions in longevity research
All targets

Stem cell

Lgr5-positive stem cells

Stem cells expressing Lgr5 that provide ongoing cell renewal

Hypotheses on this target 1

Lgr5-positive stem cellsReprogramming. Hypotheses on this target 0Transplantation. Hypotheses on this target 0Directed differentiation. Hypotheses on this target 0Proliferation. Hypotheses on this target 0Population balance. Hypotheses on this target 11

Population balance1

  • Reserve cells may extend life by restoring intestinal crypts after renewal cells are lost

    Where this hypothesis actsActive stem cells in intestinal crypts vulnerable to loss of renewing cells

    What is proposedSupport the active stem cell population to sustain routine renewal

    With whatProtein or peptide as the agent

    HowLocal, short pulses of R-spondin-1

    Possible resultPossible maintenance of routine epithelial renewal and intestinal function

    2026-10-05