Live·Open questions in longevity research
All targets

Receptor or channel

TIM-4

A protein involved in macrophage clearance of cell corpses

Hypotheses on this target 1

TIM-4Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 0Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 11Function preservation. Hypotheses on this target 0

Function restoration1

  • Restored corpse clearance can worsen aged skin by removing recoverable living cells

    Where this hypothesis actsMacrophages in aged skin during repeated mild barrier challenges

    What is proposedRestore macrophage TIM-4 activity

    With whatNot stated in the record

    HowMacrophage-specific TIMD4 manipulation; the precise restoration method is not stated

    Possible resultExpected increase in engulfment of recoverable basal keratinocytes despite normal apoptotic-corpse clearance

    2026-09-21