Receptor or channel
M3 muscarinic receptor
A receptor that supports secretory signalling in eccrine sweat gland cells
Hypotheses on this target 1
Lower level
Higher level
Blockade1
Agonism
Desensitisation
Function restoration
Function preservation
Blockade1
Cooling may prolong sweating by slowing the shutdown of receptor signals inside endosomes
Where this hypothesis actsInside eccrine sweat gland cell endosomes after heat exposure, when blood flow falls before sweating stops
What is proposedSelectively terminate persistent endosomal receptor signalling
With whatNot stated in the record
HowDevelop a spatially selective intervention against endosomal signalling while preserving the initial response and cell-surface receptor function
Possible resultPossible stabilization of SPV_8 and reduced subsequent water loss while preserving sufficient sweating during heating
2026-09-25