Live·Open questions in longevity research
All targets

Physical property of tissue

Mechanical prestress

Mechanical tension maintained within a tissue or structure

Hypotheses on this target 1

Mechanical prestressRemodelling. Hypotheses on this target 0Composition restoration. Hypotheses on this target 0Load normalisation. Hypotheses on this target 11Direct measurement. Hypotheses on this target 0

Load normalisation1

  • Clearing early senescent cells may prevent fracture union by releasing mechanical prestress

    Where this hypothesis actsImmature fracture callus after senescent-cell clearance

    What is proposedRestore the measured mechanical prestress after cell clearance

    With whatPhysical or surgical intervention

    HowExternally restore the measured prestress without restoring the cleared cells or their secretome

    Possible resultPossible rescue of subsequent bridging and mechanical strength

    2026-10-03