Live·Open questions in longevity research
All targets

Signalling molecule

Soluble BCMA

A soluble molecule proposed to inhibit nearby plasma-cell survival activity

Hypotheses on this target 1

Soluble BCMALower level. Hypotheses on this target 11Synthesis suppression. Hypotheses on this target 0Neutralisation. Hypotheses on this target 0Supplementation. Hypotheses on this target 0Accelerated excretion. Hypotheses on this target 0
  • Lower level1
  • Synthesis suppression
  • Neutralisation
  • Supplementation
  • Accelerated excretion

Lower level1

  • New antibody-producing cell clusters can kill older cells by changing nearby survival signals

    Where this hypothesis actsExtracellular space around plasma-cell survival domains in marrow

    What is proposedSelectively remove soluble BCMA to reduce its inhibitory activity

    With whatNot stated in the record

    HowSelective inhibitor removal, distinguished from changes in membrane receptors or other gamma-secretase substrates; the removal technique is not stated

    Possible resultPossible shortening of exclusion zones and rescue of resident plasma cells before death

    2026-09-21