Live·Open questions in longevity research
All targets

Enzyme

Neutrophil elastase

A protein-cleaving enzyme associated with neutrophils

Hypotheses on this target 1

Neutrophil elastaseInhibition. Hypotheses on this target 11Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition1
  • Activation
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Inhibition1

  • Vesicle removal may limit damage from elastase shielded against its natural inhibitor

    Where this hypothesis actsOn small extracellular vesicles, accessible to tissue proteins but shielded from alpha-1-antitrypsin

    What is proposedInhibit elastase activity on extracellular vesicles

    With whatSmall molecule

    HowUse a small inhibitor to overcome the proposed steric barrier; compare inhibitors with equal activity against free elastase

    Possible resultPossible improvement in tissue function and reduction in residual functional deficit SPV_6

    2026-09-30