Physical property of tissue
Cell surface geometry
The physical arrangement, height and density of molecules on cell surfaces
Hypotheses on this target 1
Remodelling1
Composition restoration
Load normalisation
Direct measurement
Remodelling1
Wider cell contacts may prevent enzyme exclusion, impair clearance and renew inflammation
Where this hypothesis actsContacts between macrophages and tissue cells or their remnants after prior damage
What is proposedRestore intermembrane spacing that permits complete engulfment
With whatPhysical or surgical intervention
HowChange the length of an inert molecular linker while keeping ligand density, receptor affinity, cell composition and the current environment constant
Possible resultPossible restoration of clearance and prevention of recurrent inflammation without changing nuclear programmes
2026-09-30