Organ structure
Cell neighborhood geometry
The spatial arrangement of cells and the pattern of which cells are adjacent within a tissue
Hypotheses on this target 1
Function restoration
Remodelling1
Tissue graft
Load normalisation
Remodelling1
Briefly lowering cell surface tension may let cells swap neighbors and durably ease tissue stress
Where this hypothesis actsDense stromal regions where steric constraints maintain a stressed cellular configuration
What is proposedRearrange cellular neighborhoods into a configuration with less residual stress
With whatNot stated in the record
HowBriefly reduce cortical tension to allow cells to exchange neighbors, then restore the original tension while retaining the new configuration
Possible resultPossible lasting reduction in damaging secretion and SPV_1 despite persistence of most initial damage
2026-09-30