Live·Open questions in longevity research
All targets

Enzyme

Acid sphingomyelinase

An enzyme involved in processing epidermal lipids

Hypotheses on this target 1

Acid sphingomyelinaseInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Replacement. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 11Cofactor removal. Hypotheses on this target 0Synthesis suppression. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Lower level
  • Higher level
  • Replacement
  • Protection from degradation1
  • Cofactor removal
  • Synthesis suppression
  • Function preservation

Protection from degradation1

  • Washing may weaken the skin barrier by activating enzymes that destroy lipid-processing enzymes

    Where this hypothesis actsStratum corneum during the elevated-pH interval after washing and before friction

    What is proposedPreserve the intact, active enzyme by preventing proteolytic cleavage

    With whatNot stated in the record

    HowInhibit serine proteases immediately after washing, before cleavage occurs

    Possible resultPossible stabilization of SPV_1 and preservation of tolerance to subsequent friction

    2026-09-25