Live·Open questions in longevity research
All targets

Regulatory protein

MYC

A protein that regulates growth

Hypotheses on this target 1

MYCInhibition. Hypotheses on this target 0Activation. Hypotheses on this target 0Lower level. Hypotheses on this target 11Higher level. Hypotheses on this target 0Protection from degradation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Inhibition
  • Activation
  • Lower level1
  • Higher level
  • Protection from degradation
  • Function restoration
  • Function preservation

Lower level1

  • Different protein lifetimes may separate spermidine-driven cell recycling from clonal growth

    Where this hypothesis actsAltered cells after a spermidine-mimetic pulse; proposed testing in intestinal organoids

    What is proposedAllow additional MYC activity to subside before feeding resumes

    With whatChange of environment or regimen

    HowResume feeding after the MYC growth pulse decays but before lysosomal function declines; experimentally prolong MYC lifetime to test this timing dependence

    Possible resultPossible reduction in absolute growth of altered cells while autophagic benefit persists

    2026-10-06