Live·Open questions in longevity research
All targets

Receptor or channel

CD1a

A lipid-binding molecule on Langerhans cells recognized by autoreactive T cells

Hypotheses on this target 1

CD1aLower level. Hypotheses on this target 0Higher level. Hypotheses on this target 0Blockade. Hypotheses on this target 11Agonism. Hypotheses on this target 0Desensitisation. Hypotheses on this target 0Function restoration. Hypotheses on this target 0Function preservation. Hypotheses on this target 0
  • Lower level
  • Higher level
  • Blockade1
  • Agonism
  • Desensitisation
  • Function restoration
  • Function preservation

Blockade1

  • Skin lipids may slow repair by blocking immune recognition and its repair signal

    Where this hypothesis actsLangerhans cells in human skin exposed to lamellar formulations containing long-chain sphingomyelins

    What is proposedBlock recognition of CD1a to test its role in barrier recovery

    With whatSmall molecule

    HowCD1a blockade in the control group; matched lamellar formulations also vary in their lipids' ability to block CD1a recognition

    Possible resultExpected reproduction of delayed barrier recovery

    2026-09-26