Big data on ageing

Ageing genes and the experiments in which changing their activity altered lifespan or age-related traits.

Genes linked to human ageing and genes that change lifespan in model organisms.

Maximum lifespan, body mass and age at maturity for more than 4,000 animal species.

Compounds that extended lifespan in model organisms, with dose, species and effect size.

Genes on which lifespan extension by dietary restriction depends.

Genes that drive or inhibit cellular senescence.

Genetic variants tested for association with human longevity, negative results included.

Lifespan of model organisms under combinations of genetic interventions.

Gene activity, epigenetic and protein data on ageing collected from many studies.

Compounds tested for lifespan effects in genetically diverse mice at three sites in parallel.

Lifespan and traits of mouse strains, including raw Interventions Testing Program data.

Biological age of human and mouse samples from public DNA methylation data, computed with many epigenetic clocks.

Mortality and life expectancy by country, year, sex and age.

Validated ages of people who lived to 105, 110 and beyond.

Single-cell gene activity in 23 mouse tissues and organs at ages from 1 to 30 months.

Cell-type atlas of many organs sampled from the same donors.

Single-cell data on human tissues from the international consortium's projects.

Standardised single-cell datasets for comparing a gene across tissues, cell types and donor groups.

Gene activity in 54 tissues from nearly 1,000 donors aged 20 to 79, and the genetic variants that change it.

Where each human protein is found across tissues, cells and subcellular structures.

Archive of gene-activity and epigenetic experiments, including many young-versus-old comparisons.

European archive of functional genomics experiments with sample descriptions.

Raw sequencing reads for reprocessing.

Raw data from proteomics experiments.

Raw data from metabolomics experiments.

Human metabolites and their concentrations in blood, urine and tissues.

Genomes, blood tests, plasma proteins, imaging and health records of 500,000 people, by application.

Examinations and lab tests of US residents linked to mortality records; the PhenoAge clock was trained on them.

Long-term follow-up of health, income and cognition in Americans over 50, including DNA methylation.

Repeated examinations of the same people since 1958, by application.

Genomes, health records and wearable data from hundreds of thousands of US residents.

Associations of genetic variants with thousands of diagnoses in Finland; summary results are open.

Published associations of genetic variants with traits, including lifespan and parental longevity.

Variant frequencies across hundreds of thousands of people and how well each gene tolerates loss of function.

Clinical significance of human genetic variants.

Individual-level data from large cohorts such as the Framingham Heart Study, by application.

Protein functions, domains, modifications and variants.

Predicted structures of more than 200 million proteins.

Experimentally determined structures of proteins and their complexes with small molecules.

Known and predicted protein interactions.

Human signalling and metabolic pathways, reaction by reaction.

Metabolic and signalling pathway maps across many organisms.

Gene functions in a shared vocabulary for enrichment analysis.

Measured activity of millions of compounds against protein targets.

Approved and experimental drugs with their targets, metabolism and interactions.

Chemical compounds, their properties and biological screening results.

Gene-activity changes in cells exposed to thousands of compounds; used to find compounds that shift cells towards a younger profile.

Evidence linking targets to diseases from genetics, experiments and literature.

Adverse drug event reports submitted to the US Food and Drug Administration.

Registered clinical trials with design, status and results.

Trials from national registries worldwide in one World Health Organization search.

Genes, mutants and phenotypes of the nematode Caenorhabditis elegans, including lifespan.

Genes, strains and phenotypes of the fruit fly Drosophila melanogaster.

Mouse genes and phenotypes of knockout lines.

Genes and phenotypes of baker's yeast, including replicative lifespan.

Vertebrate genomes and gene correspondences across species for comparing long- and short-lived animals.

Abstracts and records of more than 37 million biomedical publications.

Full texts of open-access articles.

Full texts and preprints with genes, diseases and compounds tagged automatically.

Biology preprints before peer review.

Medical and clinical preprints before peer review.

Links between papers, authors, institutions, citations and funders.

Projects funded by the US National Institutes of Health, with amounts, investigators and publications.

Patents and scholarly articles with the links between them.