Live·Open questions in longevity research

Direction

Measuring ageing

Biomarkers, ageing clocks and diagnostics that say how old a body really is

Companies

Companies in this direction

Ambition is what a company claims. Independent replication is what others have confirmed. Read the two columns together: the gap between them is where a promise runs ahead of a result.

CompanyAmbitionIndependent replicationStageHeadquarters
Biotein
Biotein is building a low-cost saliva test to measure protein markers of age-related cellular damage.
50pre seed
Deep Longevity
Deep Longevity provides AI-powered aging clocks and SaaS platforms for biological age prediction and personalized health insights.
64acquiredHong Kong
Edifice Health
Edifice Health provides inflammatory health monitoring tests to help patients and clinicians manage systemic chronic inflammation.
64San Francisco, California, United States
Generation Lab
Generation Lab offers an epigenetic SystemAge test with personalized insights across 460 biomarkers and 21 organs and systems.
81San Francisco, California, United States
Life Length
Life Length measures aging and disease biology using telomere, telomerase, oxidative stress, NAD+, and single-cell biomarker diagnostics.
32Madrid, Spain
My Aging Tests
MyAgingTests provides epigenetic biological age testing and evidence-backed tools for longevity interventions.
65United States
Sapere Bio
Sapere Bio provides biomarker testing for longevity, immune resilience, cellular senescence, and athletic performance.
63Raleigh-Durham, North Carolina, United States
Tally Health
Tally Health provides epigenetic age testing, longevity supplements, and personalized insights designed to improve healthspan and longevity.
64United States
Vero Biosciences
Vero uses proteomics and machine learning to measure organ-level biological age from a single blood draw.
71United States

Projects

Projects in this direction

ProjectScienceBreakthroughInvestment case
CHANGS
CHANGS is a newly announced 2025 Chulalongkorn University-BGI collaboration in Thailand focused on healthy aging, using omics and AI-based bioinformatics to analyze elderly health, collect volunteer samples and clinical data, and reportedly build outputs such as multi-omic aging measures and organ-aging models. The evidence supports that the project exists and has institutional backing, but not that it has yet produced validated biomarkers, intervention results, or clinical utility.
383738
Japan Longevity Consortium
Japan Longevity Consortium is a Japan-based academic consortium led from Juntendo University that is promoting a biomarker-guided, multi-component “Scientific Zen” healthspan program combining washoku-style diet, mild fasting, exercise, yoga/breathing, TEAS, far-infrared therapy, supplementation, and gut-focused management to improve cognition, immune function, and muscle function. The strongest signals are a senior university team, XPRIZE Healthspan Top 40 semifinalist status, and self-reported preliminary observational findings on epigenetic-age and autonomic outcomes; the main constraint is that the core efficacy claims are currently presented mostly on the consortium’s own site or institutional announcements, with limited methodological detail and no clearly linked peer-reviewed validation of the full program.
424255

People

People in this direction

  1. Aubrey de Greypopulariser · through Human Longevity Inc.

    SENS Foundation founder and longevity advocacy pioneer.

  2. George Churchscientist · through Generation Lab

    Led and founded major synthetic biology and genomics efforts with public work on aging reversal, gene therapy, and longevity biotechnology companies including Rejuvenate Bio.

  3. Alex Zhavoronkovpopulariser · through Deep Longevity
  4. Steve Horvathscientist · through My Aging Tests
  5. Vadim Gladyshevscientist · through Deep Longevity

    Redox biologist mapping the mechanisms and signatures of aging

  6. Eric Verdinscientist · through Edifice Health
  7. Tony Wyss-Corayscientist · through Vero Biosciences

    Neuroscientist decoding how systemic aging affects the brain

  8. David Sinclairscientist · through Tally Health
  9. Kelsey Moodyentrepreneur · through Biotein

    Drug-development entrepreneur building an integrated longevity biotech platform

  10. Peter Diamandisentrepreneur · through Human Longevity Inc.

Chronology

What happened, and when

  1. Oct 22, 2025Funding roundGeneration Lab

    seed · $11M · Accel

Hypotheses

Hypotheses under test in this direction

Published by the Omega Point engine and tagged to this direction by a classifier; the gap each one attacks is named under it

  1. Widening blood vessels creates an apparent oxygen loss at skin repair sitesSep 21, 2026The hypothesis says optical readings can fall after local blood vessel widening without reducing oxygen available to repairing skin. Matched heat and pressure tests would distinguish a sampling effect from real harm by comparing optical readings, independent tissue oxygen measurements, and functional recovery.

Forecasts

What the forecasts expect here

  1. Will at least one aging clock be accepted by a regulator as a surrogate endpoint?20% yesby Nov 1, 2026
  2. Will the FDA/CDER qualify an epigenetic clock or other biomarker of aging as a drug-development tool by 30 Jun 2029?20% yesby Nov 1, 2026