Earlier sweating after heat acclimatization may trigger a local vessel-narrowing reflex
In aging skin, sweat after heat acclimatization may trigger a local reflex that narrows blood vessels and impairs barrier repair. The mechanism would be rejected if externally applied sweat shows neither composition dependence nor a specific interaction with local alpha-adrenergic receptor blockade.
Stage of verification
- Hypothesis published2026-09-25
- Indirect evidenceAssessed at 4 of 10
- Direct testAwaited
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Where in the body
Biological function
The biological function description is being prepared
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Target map
Every target of every published hypothesis, each with the actions a hypothesis can propose on it. The targets and the actions of this hypothesis are drawn solid.

Receptor or channel
Alpha-adrenergic receptors
Receptors involved in adrenergic signalling that regulates blood vessel constriction
Where this hypothesis actsAged skin under clothing during prolonged sweat exposure after heat acclimatization
Hypotheses on this target 1
Lower level
Higher level
Blockade1
Agonism
Desensitisation
Function restoration
Function preservation

What is proposed
Blockade
Locally inhibit receptor activity to interrupt the vasoconstrictor response
With whatNot stated in the record
HowLocal alpha-adrenergic receptor blockade while maintaining the same wet exposure and accounting for effects on baseline blood flow
Possible result
Expected prevention of the additional fall in vascular conductance and reduced subsequent barrier disruption
From the recordместная блокада альфа-адренорецепторов устранит дополнительное падение проводимости.

Metabolite or ion
Extracellular electrolytes
Ions in the fluid outside cells that constitute the local electrolyte environment
Where this hypothesis actsAround sweat ducts during prolonged contact with hypotonic sweat after heat acclimatization
Hypotheses on this target 1
Supplementation
Accelerated excretion
Composition restoration1

What is proposed
Composition restoration
Adjust the local ionic composition to prevent initiation of the vasoconstrictor reflex
With whatChange of environment or regimen
HowChange the ionic composition of applied artificial sweat while controlling osmolality and keeping surface liquid quantity constant
Possible result
Possible preservation of local blood flow and epidermal barrier recovery during wet exposure
From the recordПричинным субстратом служит обратимое изменение внеклеточной ионной среды.
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The logic
The train of thought that ends in this hypothesis. Each stage is the reason the next exists. The master question narrows to a goal, the goal to an unknown nobody has closed, the unknown to the hypothesis proposed here. Every step below says what it rests on and what carries it.
Sweating might cool skin while also making it harder for skin to protect and repair itself under wet clothing. The unexpected move is to propose that prolonged sweat contact changes the local balance of dissolved salts and triggers nerves that narrow nearby blood vessels, even when the body has enough water. This is a hypothesis generated by the pipeline, not a measured result.
- Adjustment to repeated heat exposure is proposed to start sweating earlier, extending sweat contact beneath clothing.
- Relatively dilute sweat is proposed to alter the dissolved-salt environment outside cells around sweat ducts.
- The altered salt environment is proposed to activate local nerves that narrow blood vessels.
- Local vessel narrowing is proposed to override the vessel widening normally associated with heat, despite adequate whole-body water.
- Reduced local blood supply is proposed to slow repair of the skin's outer layer during continued wetness.
- Slower repair is proposed to leave the protective barrier more damaged; preventing the nerve response should preserve blood flow first and barrier protection afterward.
A cooling system starts releasing water sooner, but the lingering water trips a nearby control that partly closes the supply needed for repairs.
Where the picture breaks: The skin has no single switch linking sweat to repair. The proposed salt change, nerve response and dependence of repair on blood supply each require separate evidence.
- Master questionstep 01 of 04
A proposed therapy would restore the functional condition of middle-aged human skin toward that of younger people.
Rests on: The goal itself specifies improved skin function and younger skin as the comparison.
Stated in the chain - Goal pillarstep 02 of 04
Skin's protective responses must work together when several demands occur at once.
Rests on: The goal concerns skin function broadly; this stage treats compatibility between protective responses as one component of that function.
AssumptionThe goal does not specify which protective responses must remain compatible or establish that their incompatibility explains the difference between middle-aged and younger skin.
- Gap questionstep 03 of 04
Heat acclimatization, the body's adjustment to repeated heat exposure, could have a harmful trade-off if earlier sweating damages the skin's protective barrier and restricts blood flow without adding cooling, while less sweating preserves all three functions.S3
Rests on: The preceding stage calls for protective responses to remain compatible under simultaneous demands; this stage selects cooling, blood flow and barrier protection as the combination to examine.
AssumptionEarlier sweating after heat acclimatization is taken as the starting condition, but the supplied evidence does not establish it for the intended skin sites or population. The Chinese Journal of Physiology study from 2017 reported later sweat onset on the upper back after repeated heat exposure in nine men; its abstract neither establishes the response in middle-aged skin under clothing nor tests the proposed blood-flow and barrier mechanism.
- Hypothesisstep 04 of 04
Prolonged contact with relatively dilute sweat is proposed to change dissolved salts around sweat ducts, the channels that carry sweat to the surface. Those changes would activate vessel-narrowing nerves, reduce local blood supply and slow repair of the skin's outer layer during continued wetness.
Rests on: The preceding question supplies the proposed conflict between sweating, blood flow and barrier protection. The endpoint supplies a local salt-sensitive nerve response as its proposed explanation and predicts that interrupting that response would preserve blood flow and subsequently the barrier.
Stated in the chain
What is carried, and what is not. Two screened sources support part of the first link: Journal of Thermal Biology (2020, abstract only; S1) reported changes in local sweating rate and sweat composition, and Temperature (2024; S2) reported increased sweating rate and reduced sweat sodium concentration in endurance-trained athletes; neither establishes earlier onset or the proposed local nerve response and barrier damage in middle-aged skin beneath clothing. None of the supplied sources establishes the sequence end to end.S1S2
Where the reasoning is carried by something unstated · 2
- Goal pillar. The goal does not specify which protective responses must remain compatible or establish that their incompatibility explains the difference between middle-aged and younger skin.
- Gap question. Earlier sweating after heat acclimatization is taken as the starting condition, but the supplied evidence does not establish it for the intended skin sites or population. The Chinese Journal of Physiology study from 2017 reported later sweat onset on the upper back after repeated heat exposure in nine men; its abstract neither establishes the response in middle-aged skin under clothing nor tests the proposed blood-flow and barrier mechanism.
How a result here could mislead · 3
- A blocker could raise blood flow on its own, making a general vessel-widening effect look like selective prevention of the proposed sweat-triggered response. What closes it: The design already requires confirmation that the blocker works and accounting for its effect on starting blood flow. The decisive comparison must establish whether alpha-adrenoceptor blockade, which prevents vessel-narrowing signals from acting through their receptors, specifically removes the additional response to the proposed sweat composition rather than merely increasing flow across conditions.
- A response to artificial sweat could be attributed to particular dissolved salts when it actually reflects a difference in total dissolved-particle concentration; conversely, no response could reflect failure to change the environment around the sweat ducts. What closes it: Specify the artificial-sweat compositions and hold osmolality, the concentration of dissolved particles per mass of water, constant when changing the salts. Temperature, surface liquid, friction and whole-body water must also remain matched as proposed. A negative result needs evidence that the intended local salt change occurred; the supplied specification does not provide a criterion for confirming that change.
- Less barrier damage after nerve blockade could be read as proof that restored blood flow caused the protection, although the proposed test does not isolate that causal link or fully separate the rival explanations. What closes it: Measure the blood-flow response before subsequent barrier damage, define the barrier measurement in advance, and establish whether restoring flow independently produces the same protection. To distinguish the supplied rivals, control protein-cutting enzyme activity in the applied liquid and account for changes in heat and touch signals; matching wetness alone does not separate those routes.
What would make this wrong. The specified distinguishing mechanism would be contradicted if, with the intended local salt exposure and effective nerve blockade confirmed, the additional blood-flow drop depended on neither sweat composition nor its specific interaction with blockade. If preventing the blood-flow drop left subsequent barrier damage unchanged under the same wet conditions, the proposed link from restricted blood supply to barrier damage would also fail. The supplied material gives no numerical decision thresholds and does not define its named outcome codes.
What it would change. If the mechanism held, restoring youthful skin function would require considering whether an earlier cooling response compromises blood supply and barrier repair during prolonged wetness. Preventing the proposed local nerve response would become a candidate approach for preserving several functions together. Even a successful local test would not establish a therapy that restores middle-aged skin to a younger state, demonstrate lasting benefit, or show that blocking the response preserves whole-body cooling.
Sources read · 10
Sweat rate and sweat composition during heat acclimation. · Journal of thermal biology · 2020
“Relative to HA day 1, LSR was increased at the final day of HA (day 10) (arm: +58%, P < 0.001; back: +36%, P < 0.05).”
Does not settle: Источник подтверждает изменения локальной скорости потоотделения и состава пота при акклиматизации у восьми участников, но не устанавливает более раннее начало потоотделения, местный сосудосуживающий рефлекс, симпатическую активацию, изменения перфузии или барьера кожи, возрастную кожу, участки под одеждой, гидратацию либо показатели SPV_8 и SPV_1.
Time-course for onset and decay of physiological adaptations in endurance trained athletes undertaking prolonged heat acclimation training. · Temperature (Austin, Tex.) · 2024
“HEAT improved time for exhaustion by 15 min ( p < 0.001) in the 40°C test, increased sweat rate by 0.44 L/hour ( p < 0.001), and lowered sweat sodium concentration [Na + ] by 14.1 mmol/L ( p = 0.006) from pre- to post-HA”
Does not settle: The source does not test a local aquagenic vasoconstriction reflex, periductal electrolyte changes, sympathetic vasoconstrictor endings, skin perfusion, epidermal recovery, clothing-covered skin, hydration, older skin, or SPV_8/SPV_1.
Effect of Intensive and Repetitive Heat Exposure on the Sudomotor Activity. · The Chinese journal of physiology · 2017
“As a typical data (upper back), sweat onset time increased by 33.6% (P < 0.05) after heat acclimation.”
Does not settle: В абстракте не изучались местный сосудосуживающий рефлекс, электролитная среда пота, симпатические окончания, кожная перфузия, эпидермальный барьер или показатели SPV_8 и SPV_1. Исследование включало девять мужчин и оценивало потоотделение после повторного теплового воздействия.
Swimming in warm water is ineffective in heat acclimation and is non-ergogenic for swimmers. · Scandinavian journal of medicine & science in sports · 2015
“After accounting for CON, HA did not confer any clear expansion of plasma volume [1.9% (95% CI: 7.7)], reduction in heart rate during standardized cycling exercise [1 b/min (9)], reduction in Tre during rest [+0.1 °C (0.1)] or exercise, or change in sudomotor function.”
Does not settle: Источник не изучает местный сосудосуживающий рефлекс, электролитную среду вокруг выводных протоков, кожную перфузию, эпидермальный барьер, возрастную кожу, участки под одеждой или показатели SPV_8 и SPV_1. Он также не устанавливает эффект других способов и режимов тепловой акклиматизации.
The Effects of Heat Adaptation on Physiology, Perception and Exercise Performance in the Heat: A Meta-Analysis. · Sports medicine (Auckland, N.Z.) · 2016
“HA had a moderate-to-large beneficial effect on lowering core body temperature before and during exercise, maintaining cardiovascular stability, and improving heat-loss pathways.”
Does not settle: This abstract does not establish earlier sweating, a local sweat-induced vasoconstrictor reflex, electrolyte changes around sweat ducts, sympathetic activation, effects in aged or clothed skin, epidermal recovery, hydration-specific effects, reversibility of an extracellular ionic mechanism, or effects on SPV_8 or SPV_1.
Postsynaptic cutaneous vasodilation and sweating: influence of adiposity and hydration status. · European journal of applied physiology · 2018
“Numerous studies have demonstrated that hyperosmolality impairs heat loss responses as evidenced by a delayed onset threshold of both sweating and skin blood flow (Fortney et al. ; Takamata et al. , ; Shibasaki et al. ; Lynn et al. ), with no effect on the thermosensitivity of either response”
Does not settle: Источник изучает системное повышение осмолярности крови при пассивном нагревании у молодых здоровых взрослых. Он оставляет открытыми местный эффект гипотонического пота, симпатический сосудосуживающий рефлекс, возрастную кожу, участки под одеждой, эпидермальное восстановление, гидратацию и показатели SPV_8 и SPV_1.
Age-related differences in postsynaptic increases in sweating and skin blood flow postexercise. · Physiological reports · 2014
“Human aging is associated with attenuated sweating and skin vasodilation during exercise (Anderson and Kenney ; Kenney and Anderson ; Tankersley et al. ; Inoue et al. ; Larose et al. , , ).”
Does not settle: Источник не изучает тепловую акклиматизацию, раннее потоотделение, контакт кожи с гипотоническим потом, локальный сосудосуживающий рефлекс, электролитный механизм, участки под одеждой, восстановление эпидермиса или показатели SPV_8 и SPV_1.
Reduced dietary intake induces body fluid hypotonicity via alterations in water and energy metabolism. · The Journal of physiology · 2025
“Skin blood flow in the non‐glabrous regions of the chest (SkBF chest ) and forearm (SkBF forearm ) were assessed using laser Doppler flowmetry”
Does not settle: Фрагмент описывает измерения кровотока кожи и локального потоотделения, но не устанавливает эффект акклиматизации, местный сосудосуживающий рефлекс, роль электролитов пота, возрастной кожи, участков под одеждой, восстановления эпидермиса или SPV_8 и SPV_1.
Measurements of transepidermal water loss in newborn infants. · Clinics in perinatology · 1985
“Simultaneous measurements of evaporation rate and skin blood flow have shown that the skin blood flow increases at a lower body temperature than the evaporation rate”
Does not settle: This newborn-infant abstract does not establish heat-acclimatization effects, a sweat-induced local vasoconstrictor reflex, extracellular ionic mechanisms, effects in aged skin or clothed sites, epidermal recovery, hydration status, or SPV_8 and SPV_1 outcomes.
Transepidermal water loss during halogen spotlight phototherapy in preterm infants. · Pediatric research · 2002
“Among preterm infants there is a relationship between skin blood flow and transepidermal water loss (TEWL).”
Does not settle: It does not establish sweating after heat acclimatization, a local vessel-narrowing reflex, electrolyte-mediated mechanisms, sympathetic activation, effects in aged skin or clothed sites, epidermal recovery, hydration status, or SPV outcomes.
The gap this hypothesis explains
Would earlier sweating that harms skin protection and circulation without extra cooling undermine heat adaptation’s benefits?
Original wording · exactly as the pipeline generated it
Опровергнет ли пользу тепловой акклиматизации результат, при котором более раннее потоотделение усиливает повреждение влажного барьера и ограничение кровотока без дополнительного охлаждения, а меньшая секреция сохраняет все три функции?
What this question is asking
The question asks whether becoming accustomed to heat remains beneficial if earlier sweating worsens skin protection and blood flow without improving cooling. It compares earlier sweating after repeated heat exposure with producing less sweat, asking whether the latter preserves the skin’s protective barrier, blood flow through the skin, and cooling together. It conditionally assumes that earlier sweating causes those harms and that less sweating preserves all three functions; the supplied sources do not establish that comparison. The phrase “wet barrier” is not defined in the input, leaving unclear whether it means the skin’s protective barrier under wet conditions or something else. The stated application concerns skin function in middle-aged people, but the supplied evidence does not establish restoration to the function of younger skin.
- Heat adaptation or heat acclimatization
- Changes in the body following repeated exposure to heat. The supplied sources describe several responses, so the term names a collection of changes rather than one effect of sweating.
- Sweat secretion, sweat rate, and earlier sweating
- Sweat secretion is the release of sweat onto the skin; sweat rate is the amount released over time. Earlier sweating concerns when release begins, which is different from how much sweat is produced, and the input does not specify the reference used to define “earlier.”
- Skin barrier
- The skin’s protective function that limits water loss. Damage to this barrier and the amount of sweat released are distinct features in the proposed comparison.
- Wet barrier
- An undefined expression in the supplied question. It may refer to the skin barrier under wet conditions, but the input does not establish that meaning or a distinct structure with this name.
- Skin blood flow or skin circulation
- Blood moving through vessels in the skin. The question treats preservation of this flow as one of three outcomes, but a lower measured flow alone does not establish harmful restriction, as the temperature-dependent comparison in S10 illustrates.
- Body-temperature regulation and cooling
- Body-temperature regulation is control of the body’s temperature; cooling is removal of heat. The question asks whether earlier sweating produces additional cooling, which is a separate outcome from releasing more sweat.
- Internal body temperature
- Temperature within the body, rather than at the skin surface. It is an outcome in S3 and a comparison condition in S10.
- Physiological strain, heat strain, and heat tolerance
- Physiological strain is the burden placed on the body; heat strain is that burden during heat exposure. Heat tolerance describes the ability to cope with heat, rather than a single skin measurement.
- Water loss through the skin
- Water passing through the skin to the surrounding air, termed transepidermal water loss in the supplied sources. S8 distinguishes this measurement from heat-related sweating, so they cannot simply be treated as the same output.
- Ichthyosis
- The skin-disease context of S5. Its supplied quote concerns barrier dysfunction, water loss, and inflammation, rather than heat adaptation.
- Inflammation
- A tissue response associated with irritation or injury. S5 reports it as a consequence of skin-barrier dysfunction but does not establish the proposed sweating pathway.
- Sweat dermatitis
- A skin condition associated with sweat and involving skin irritation or inflammation. S6 reports measurements from affected areas, without establishing the effect of earlier sweating after heat adaptation.
- Wearable skin probe
- A measuring device worn on the skin. S8 describes its ability to distinguish types of water loss and follow skin drying and restoration of water; that measurement capability does not establish the proposed benefit or harm.
Earlier sweating increases wet-barrier damage and blood-flow restriction without additional cooling, whereas lower sweat secretion preserves barrier function, blood flow, and cooling.
Sweat is fluid released onto the skin, the skin barrier limits water loss, and skin blood flow is blood moving through vessels in the skin. The question conditionally assumes that starting to sweat earlier damages that protection and restricts circulation without improving cooling, while producing less sweat avoids those costs. If established, this comparison would provide a reason to question the benefit of earlier sweating in those conditions.
The supplied search results did not return work establishing this combined comparison. The question presents it as a possible result, so its absence from the sources does not make the scenario false. S6 reports increased water loss through affected skin in sweat dermatitis, but does not establish damage caused by earlier sweating after heat adaptation. S3 reports cooling disadvantages from delayed and insufficient sweating in older people, while S10 reports higher arm blood flow after heat adaptation at the same internal temperature; both limit a general interpretation of the proposed harm.S3S6S10
The same question asked without the part nothing read establishes:
- Does earlier sweating after repeated heat exposure worsen skin protection or skin blood flow without improving cooling, compared with producing less sweat?
- In middle-aged people, how does adaptation to repeated heat exposure affect skin protection, skin blood flow, and cooling together?
- The proposed harmful tradeoff occurs If earlier sweating damages skin protection and restricts blood flow without improving cooling, while less sweating preserves all three, earlier sweating offers no compensating cooling benefit in that comparison. This would challenge its benefit under the examined conditions, but would not by itself overturn benefits of heat adaptation in other conditions.
- Less sweating compromises cooling If producing less sweat reduces cooling, the proposed preservation of all three functions fails. Any advantage for skin protection or circulation would then coexist with a cooling cost, preventing the comparison from establishing that less sweating is better overall.
- Earlier sweating does not cause the proposed harms If earlier sweating preserves skin protection and blood flow, the proposed damaging pathway is absent. If it also improves cooling, the comparison would support a benefit of earlier sweating under those conditions.
The proposed tradeoff connects the timing and amount of sweating to cooling, skin protection, and blood flow. If earlier sweating caused damage without adding cooling, that result would count against its benefit under the conditions examined. If less sweating instead reduced cooling, preserving another skin function would not establish an overall benefit: S3 reports that delayed and insufficient sweating in older people can increase internal body temperature and heat strain. Treating either outcome as universal could therefore misrepresent the balance between protecting skin and controlling body temperature.
The mechanism it proposes
The engine's own statement of the hypothesis, in full.
Предполагается, что раннее потоотделение после акклиматизации запускает местный аквагенный сосудосуживающий рефлекс: длительный контакт с собственным гипотоническим потом изменяет электролитную среду вокруг выводных протоков и активирует симпатические сосудосуживающие окончания. В возрастной коже этот ответ распространяется на участки под одеждой и способен подавлять тепловую вазодилатацию при сохранённой общей гидратации. Снижение местной перфузии замедляет восстановление эпидермиса во время влажной нагрузки, поэтому меньшая секреция сохраняет одновременно кровоток и барьер. Причинным субстратом служит обратимое изменение внеклеточной ионной среды. Предотвращение запуска рефлекса должно стабилизировать SPV_8 и вторично SPV_1.
Testing and possible results
The prediction that would tell it apart
A hypothesis that predicts what its rivals predict is not worth running an experiment over. This is the observation on which this one differs.
При одинаковых температуре, количестве поверхностной жидкости, трении и системной гидратации нанесение искусственного пота с составом, соответствующим состоянию после акклиматизации, вызовет быстрое локальное падение сосудистой проводимости на предплечье. Изменение ионного состава при контроле осмоляльности или местная блокада альфа-адренорецепторов устранит дополнительное падение проводимости. При сохранении той же влажной нагрузки блокада также уменьшит последующее нарушение барьера. Эффект должен воспроизводиться без действующей секреции, при нанесении жидкости извне. Отсутствие зависимости от состава жидкости и специфического взаимодействия с адренергической блокадой опровергнет механизм.
States a measurable outcome; comparing rivals needs more conditions. The prediction specifies an observable decrease in vascular conductance under controlled conditions, interventions that eliminate the additional decrease, and an explicit rejection condition. No rival prediction is supplied. Only a bench experiment would settle it.
What testing it would take
The engine's own read on whether this is testable with methods that already exist.
Возможны парные локальные пробы с искусственным потом, лазерной оценкой перфузии, измерением артериального давления для расчёта сосудистой проводимости и исследовательским микродиализом. Ладонная поверхность служит положительным контролем известного ответа на погружение в воду; основная проверка проводится на коже под одеждой. Следует отдельно подтвердить действие блокады и учесть её влияние на исходный кровоток.
Other explanations
Every other hypothesis the engine wrote for the same gap, and the observation that would separate the two.
При одинаковых температуре, количестве поверхностной жидкости, трении и системной гидратации нанесение искусственного пота с составом, соответствующим состоянию после акклиматизации, вызовет быстрое локальное падение сосудистой проводимости на предплечье. Изменение ионного состава при контроле осмоляльности или местная блокада альфа-адренорецепторов устранит дополнительное падение проводимости. При сохранении той же влажной нагрузки блокада также уменьшит последующее нарушение барьера. Эффект должен воспроизводиться без действующей секреции, при нанесении жидкости извне. Отсутствие зависимости от состава жидкости и специфического взаимодействия с адренергической блокадой опровергнет механизм.
- What would separate them
Confusing evaporation with sweat buildup may disrupt sweating and skin blood flow predicts: В перекрёстной пробе изменяют согласованность слабых температурных и тактильных сигналов, сохраняя среднюю температуру кожи, фактическое испарение, состав пота и суммарную механическую нагрузку. На отдельном участке, защищённом от этой стимуляции, регистрируют секрецию и сосудистую проводимость. Гипотеза предсказывает, что увеличение различимости испарения и накопления жидкости изменит удалённый вегетативный ответ ещё до изменения теплового баланса. Контрольные несогласованные сигналы той же интенсивности такого эффекта не дадут. Если меняется только субъективное ощущение влажности, а секреция и кровоток остаются прежними, причинная гипотеза опровергнута.
- Rival 02 of 02Earlier sweating may damage skin by prolonging contact with active sweat enzymes
Not yet published.
What would separate themEarlier sweating may damage skin by prolonging contact with active sweat enzymes predicts: Пот одного участника разделяют на исходную пробу, пробу после селективного удаления KLK8 и пробу с возвращением активного фермента до исходной активности. На сопоставимых эксплантатах кожи при одинаковых объёме жидкости, pH, солёности, температуре и трении удаление фермента уменьшит проницаемость, отделение корнеоцитов и появление продуктов протеолиза; возвращение активного фермента восстановит повреждение. Каталитически неактивный белок эффекта не восстановит. Если подтверждённое подавление активности не меняет повреждение, предложенный KLK8-зависимый механизм опровергнут.
Why this is not the mainstream account
The engine is asked to say what its hypothesis would overturn and what would surprise a specialist. This is its answer.
Wilder-Smith и Chow зарегистрировали уменьшение кровотока при вызванном погружением сморщивании кожи пальцев. Это подтверждает возможность сосудосуживающего ответа на намокание, но не доказывает предложенный механизм после акклиматизации. [Water-immersion wrinkling is due to vasoconstriction](https://pubmed.ncbi.nlm.nih.gov/12635117/).
Физиология терморегуляции, учебная глава «Регуляция температуры тела и лихорадка», раздел о тепловой акклиматизации. Пересмотра потребует модель, в которой усиленная секреция способствует охлаждению, а ограничение кожного кровотока преимущественно объясняется тепловыми и системными гемодинамическими сигналами: собственный пот окажется самостоятельным местным сигналом, способным подавлять доставку тепла к поверхности.
Замена только состава жидкости на поверхности предплечья обратимо переключит знак сосудистой реакции при неизменных температуре тела и гидратации; адренергическая блокада сохранит барьер при прежнем количестве пота. Это покажет, что усиленная секреция может непосредственно включать локальное противодействие терморегуляции.
В целевом поиске по сочетанию акклиматизации, пота, намокания и вазоконстрикции не найден обзор, утверждающий, что этот рефлекс определяет неблагоприятный эффект акклиматизации в возрастной коже под одеждой. Аквагенная вазоконстрикция пальцев уже известна; новым является утверждение о её доминирующей роли при контакте с собственным потом на других участках. Отрицательный поиск не доказывает полного отсутствия такой гипотезы в литературе, поэтому соответствие критерию новизны предварительное.
What stands behind it
Which of the figures above have a study behind them, which are the engine's own, and what it would take to refute the hypothesis. This audit never judges the idea.
This hypothesis states no figure and cites no study, so there is nothing here to trace.
What it would take to refute it. Nothing already retrieved carries the prediction’s terms and it names no measurement this layer can route to a public dataset, so the bench is the residual — not a finding against it.
0 citation handles extracted; 1 Europe PMC search run; 0 records examined; 0 sources stored for enrichment, 0 with full text. A citation that did not resolve is a bibliographic failure, not proof that no such paper exists, and no hypothesis is blocked by this audit.