Omega Point · Lab
Hypotheses
Every hypothesis every run has written, newest run first. Each row says where it is: being named, waiting for the rest of its run, checked for duplicates, approved and being explained, published. A duplicate names the earlier hypothesis it restates. A published row links to its public page; nothing else is a link.
Run: pipeline-cf15f9184116the run
| Hypothesis▲ | Question asked▲ | Date▼ | Engine▲ | Lens▲ | Status▲ |
|---|---|---|---|---|---|
| Restored function may halt disabling illness and self-care failure enough to predict survival gains IH_Q_L3_M_G1_1_01 · #0 Sustained restoration of mobility, cognition and everyday independence may interrupt disabling illness and self-care failure enough to predict survival and independent-life gains across drug mechanisms; precisely opposite late effects despite matched six-month joint recovery effects would refute this. Explains the gap: Do early improvements in functional recovery predict later gains in survival and independent life across drug mechanisms, or can indistinguishable early responses conceal opposite later treatment effects? Proxy gap | Как измерить эффективность препаратов, продлевающих жизнь человеку, не отслеживая всю его жизнь до смерти и не тратя 20-80 лет на исследование? | 2026-09-27 21:59 | 1.3 | recovery causal closure | Approved Approved · explanation queued |
| Persistent injury may make restored function temporary and shorten independent life IH_Q_L3_M_G1_1_02 · #1 Drugs may restore function through compensation while residual injury drives later disability. At matched early recovery and joint-domain occupancy, precise absence of both excess recurrence and better held-out prediction despite residual lesions would reject this pathway. Explains the gap: Do early improvements in functional recovery predict later gains in survival and independent life across drug mechanisms, or can indistinguishable early responses conceal opposite later treatment effects? Proxy gap | Как измерить эффективность препаратов, продлевающих жизнь человеку, не отслеживая всю его жизнь до смерти и не тратя 20-80 лет на исследование? | 2026-09-27 21:59 | 1.3 | trajectory hysteresis | Approved Approved · explanation queued |
| Selection after randomization may create a false link between early recovery and later survival IH_Q_L3_M_G1_1_03 · #2 The proposed link between early recovery and later survival may reflect selection of disabled survivors who return for assessment. A precise, clinically important early contrast across all randomized participants plus externally calibrated prediction of later treatment effects would reject selection as sufficient. Explains the gap: Do early improvements in functional recovery predict later gains in survival and independent life across drug mechanisms, or can indistinguishable early responses conceal opposite later treatment effects? Proxy gap | Как измерить эффективность препаратов, продлевающих жизнь человеку, не отслеживая всю его жизнь до смерти и не тратя 20-80 лет на исследование? | 2026-09-27 21:59 | 1.3 | Measurement and interpretation | Approved Approved · explanation queued |
| Symptom relief may increase harmful activity before tissue tolerance recovers IH_Q_L3_M_G1_1_04 · #3 Early symptom relief may increase hazardous activity faster than tissue tolerance recovers, causing later disability despite similar early recovery. A treatment-by-program interaction absent despite a precisely confirmed change in unsafe exposure would weaken this pathway. Explains the gap: Do early improvements in functional recovery predict later gains in survival and independent life across drug mechanisms, or can indistinguishable early responses conceal opposite later treatment effects? Proxy gap | Как измерить эффективность препаратов, продлевающих жизнь человеку, не отслеживая всю его жизнь до смерти и не тратя 20-80 лет на исследование? | 2026-09-27 21:59 | 1.3 | behavioral exposure substitution | Approved Approved · explanation queued |
| Dependence between functions may alter later independent life despite equal early gains IH_Q_L3_M_G1_1_05 · #4 Mobility, cognition and everyday independence may improve equally in isolation yet differ in simultaneous preservation, changing later independent life. Precisely equivalent dependence and joint-state trajectories with persistent late divergence would reject this as sufficient. Explains the gap: Do early improvements in functional recovery predict later gains in survival and independent life across drug mechanisms, or can indistinguishable early responses conceal opposite later treatment effects? Proxy gap | Как измерить эффективность препаратов, продлевающих жизнь человеку, не отслеживая всю его жизнь до смерти и не тратя 20-80 лет на исследование? | 2026-09-27 21:59 | 1.3 | joint function dependence | Approved Approved · explanation queued |