C-QLGHwhole brain preservation, aldehyde-stabilized cryopreservation, connectomics
0-100 chain-logic scale · 15 dimensions · scored on public evidence
SPEAKERS ▶Matt Angle, PhD (CEO, Paradromics) ▶Kenneth Hayworth, PhD, (President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)) ▶Robert McIntyre (CEO at Nectome) ▶Jeremy Maitin-Shepard (Software Engineer–Connectomics at Google) Achieving faithful reconstruction of preserved brains requires more than detailed imaging, it demands rigorous functional validation. To prove that preservation methods are viable, researchers must pair anatomical reconstruction with behavioral outcomes, demonstrating that simulated models can replicate learned behaviors. Setting this standard, even before current capabilities make it feasible, establishes a clear benchmark for the fidelity necessary in connectomics. Success also depends on flawless preservation: even minor, localized errors in tissue integrity can irreversibly compromise connectivity. Any method intended for practical use must therefore meet t
💡 What if you never had to die? Not science fiction — real science. Researchers and futurists believe brain preservation and uploading could unlock digital immortality within our lifetime. Kenneth Hayworth, neuroscientist & futurist, is developing nanometer-scale brain mapping at the Howard Hughes Medical Institute. The Brain Preservation Foundation is pushing research into aldehyde-stabilized cryopreservation — preserving the brain slice by slice at the synaptic level. Once mapped, your entire connectome (the wiring of your thoughts, memories, and personality) could be uploaded into an AI system or synthetic body. Imagine your grandson talking to you 100 years after your death, not through a photo — but through your digital self, fully aware, responsive, and alive. This is Reincarnation 2.0 — powered by AI. But here’s the terrifying question: 👉 If your mind is uploaded… will it still be you? 👉 Can AI recreate emotions, intuition — even a soul? 👉 Or are we building a future
In this episode, we are delving into the fascinating topic of mind uploading. We suspect this idea is about to explode into public consciousness, because Nick Bostrom has a new book out shortly called “Deep Utopia”, which addresses what happens if superintelligence arrives and everything goes well. It was Bostrom’s last book, “Superintelligence”, that ignited the great robot freak-out of 2015. Our guest is Dr Kenneth Hayworth, a Senior Scientist at the Howard Hughes Medical Institute's Janelia Farm Research Campus in Ashburn, Virginia. Janelia is probably America’s leading research institution in the field of connectomics – the precise mapping of the neurons in the human brain. Kenneth is a co-inventor of a process for imaging neural circuits at the nanometre scale, and he has designed and built several automated machines to do it. He is currently researching ways to extend Focused Ion Beam Scanning Electron Microscopy imaging of brain tissue to encompass much larger volumes than are
Ken Hayworth is the president of the Brain Preservation Foundation and a strong proponent of chemical brain preservation. During my Singularity 1 on 1 interview with Ken, we talk about a variety of topics such as his background in electron-microscopy and how he got interested in it; the motivation behind his work; his skepticism towards […]
#neuroscience #connectomics #optogenetics #cyonics #genetics #braincomputerinterface #minduploading #brainpreservation Kenneth Hayworth is the President and Co-Founder of the Brain Preservation Foundation, he is currently a Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus a leading research institution in the field of connectomics Hayworth is co-inventor of the Tape-to-SEM process for high-throughput volume imaging of neural circuits at the nanometer scale and he designed and built several automated machines to implement this process. Hayworth received a Ph.D. in Neuroscience from the University of Southern California for research into how the human visual system encodes spatial relations among objects. Hayworth calls for the implementation of an emergency glutaraldehyde perfusion procedure in hospitals, and for the development of a whole-brain embedding procedure that can demonstrate perfect ultrastructure preservation across an entire human b
This is a Brain Preservation Foundation Neuroscience Journal Club presentation (presented by Kenneth Hayworth) on the paper "Spatial connectivity matches direction selectivity in visual cortex" by Rossi, Harris, and Carandini published in the journal Nature on November 11th 2020. Here is a link to the paper: https://www.nature.com/articles/s41586-020-2894-4 Link to Wikersham et al. 2007 “Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons”: https://www.sciencedirect.com/science/article/pii/S0896627307000785 This video presents the results of these papers and discusses the following concepts: 1. Visual receptive fields in mouse visual cortex 2. Orientation selectivity 3. Direction selectivity 4. Rabies virus tracing of neural circuits 5. GCamP6 calcium imaging 6. Presynaptic neuronal ensemble 7. Connectomics
On Sunday, September 27, 2020, at 1 p.m. U.S. Pacific Time, the U.S. Transhumanist Party invites Dr. Kenneth Hayworth, President and Co-Founder of the Brain Preservation Foundation (BPF), and Dr. Robert McIntyre, CEO of Nectome, Inc., to discuss the prospects for future structural preservation of the human brain in ways that could preserve memory and personality. The conversation will include a philosophical component where the continuity of consciousness and the prerequisites for preserving an individual’s “I-ness” or unique vantage point upon the world will be explored. Find out more about the Brain Preservation Foundation here: https://www.brainpreservation.org/ Find out more about Dr. Kenneth Hayworth here: https://www.brainpreservation.org/team/kenneth-hayworth/ Watch Dr. Hayworth’s description of the mission of the BPF here: https://www.youtube.com/watch?v=v2scSuw0om8 Watch Dr. McIntyre's presentation to the Long Now Foundation, "Engram Preservation: Early Work Towards Mi
Ken Hayworth: Connectomics is Revolutionizing Neuroscience - Could We Scan a Full Mouse Brain Connectome in 10 Years? In "2030: Beyond the Film" Director Johnny Boston discusses the futurist FM-2030, the Coronavirus Pandemic, and a range of urgent issues in the medical, philosophical, longevity & futurist space with leading voices. In this episode, Boston talks with Neuroscientist Ken Hayworth about a range of topics, including brain preservation research, the Brain Preservation Foundation, recent advances and proposals in the field of Connectomics, and why Hayworth believes mainstream scientists are reluctant to embrace ideas around brain preservation as a end-of-life hospital option. About Ken Hayworth (via the Brain Preservation Foundation): Kenneth Hayworth, President and Co-Founder of the Brain Preservation Foundation, is currently a Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) in Ashburn, Virginia. JFRC is perhaps the leading r
Ken Hayworth: It's Time to Develop Regulated Brain Preservation in Hospitals In "2030: Beyond the Film" Director Johnny Boston discusses the futurist FM-2030, the Coronavirus Pandemic, and a range of urgent issues in the medical, philosophical, longevity & futurist space with leading voices. In this episode, Boston talks with Neuroscientist Ken Hayworth. About Ken Hayworth (via the Brain Preservation Foundation): Kenneth Hayworth, President and Co-Founder of the Brain Preservation Foundation, is currently a Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) in Ashburn, Virginia. JFRC is perhaps the leading research institution in the field of connectomics in the United States. At JFRC, Hayworth is currently researching ways to extend Focused Ion Beam Scanning Electron Microscopy (FIBSEM) imaging of brain tissue to encompass much larger volumes than are currently possible. For an overview of this work see his recent review paper and online
Ken Hayworth: Neuroscientists Need to Embrace the Implications of their Rapidly Advancing Science In "2030: Beyond the Film" Director Johnny Boston discusses the futurist FM-2030, the Coronavirus Pandemic, and a range of urgent issues in the medical, philosophical, longevity & futurist space with leading voices. In this episode, Boston talks with Neuroscientist Ken Hayworth about a range of topics, including brain preservation research, the Brain Preservation Foundation, recent advances and proposals in the field of Connectomics, and why Hayworth believes mainstream scientists are reluctant to embrace ideas around brain preservation as a end-of-life hospital option. About Ken Hayworth (via the Brain Preservation Foundation): Kenneth Hayworth, President and Co-Founder of the Brain Preservation Foundation, is currently a Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) in Ashburn, Virginia. JFRC is perhaps the leading research institution
Beyond 2030: Neuroscientist Ken Hayworth Wants Everyone to Seriously Think About Death - And Mind Uploading (Part 1 of 2) In "2030: Beyond the Film" Director Johnny Boston discusses the futurist FM-2030, the Coronavirus Pandemic, and a range of urgent issues in the medical, philosophical, longevity & futurist space with leading voices. In this episode, Boston talks with Neuroscientist Ken Hayworth about a range of topics, including brain preservation research, the Brain Preservation Foundation, and Hayworth's efforts to turn a particular type of Brain Preservation into an accepted medical procedure performed in hospitals. About Ken Hayworth (via the Brain Preservation Foundation): Kenneth Hayworth, President and Co-Founder of the Brain Preservation Foundation, is currently a Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) in Ashburn, Virginia. JFRC is perhaps the leading research institution in the field of connectomics in the United S
This is a Brain Preservation Foundation Neuroscience Journal Club presentation (presented by Kenneth Hayworth) on the paper "Locally coordinated synaptic plasticity of visual cortex neurons in vivo" by Sami El-Boustani, Jacque P. K., Vincent Breton-Provencher, Graham W. Knott, Hiroyuki Okuno, Haruhiko Bito, and Mriganka Sur, published in the journal Science on June 22nd 2018. Here is a link to the paper: http://science.sciencemag.org/content/360/6395/1349 This paper offers one of the most direct tests I have ever seen of the textbook theories about how learning occurs in the brain. The authors induce learning in a single visual neuron (a layer 2-3 pyramidal cell in mouse V1) using well-timed optogenetic stimulation. Using this method they literally shift the visual receptive field location of that neuron. Using fluorescence imaging they see that some of the neurons’s dendritic spine synapses grow while others shrink in response to this learning paradigm. And using calcium imaging, t
This is a Brain Preservation Foundation Neuroscience Journal Club presentation (presented by Kenneth Hayworth) on the paper "Interregional synaptic maps among engram cells underlie memory formation" by Choi et al. published in the journal Science on April 27th 2018. Here is a link to the paper: http://science.sciencemag.org/content/360/6387/430 This video presents the results of the paper and discusses the following concepts: 1. Cell Assemblies 2. Neuronal Ensembles 3. Memory Engram Cells 4. Contextual Fear Conditioning 5. c-fos engram labeling 6. dual-eGRASP (green fluorescent protein reconstitution across synaptic partners) 7. Hippocampus (CA3 to CA1) 8. Synaptic basis of memory
This is a Brain Preservation Foundation Journal Club presentation (presented by Kenneth Hayworth) on the paper "Structure–stability–function relationships of dendritic spines" by Kasai et al. published in the journal Trends in Neurosciences Vol.26 No.7 July 2003. Here is a link to the paper: https://www.sciencedirect.com/science/article/pii/S0166223603001620 This is a review paper that is based mainly on the Primary Research Paper "Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons" by Matsuzaki et al. published in the journal Nature Neuroscience in 2001. Here is a link to that paper: https://www.nature.com/articles/nn736 This video presents the results of the paper and discusses the following concepts: 1. Dendritic spines 2. Two photon microscopy of the structure of synapses 3. 3D electron microscopy of the structure of synapses 4. Immunogold labeling of glutamate receptors 5. Two photon glutamate uncaging experiments 6. Synapti
This is a Brain Preservation Foundation Journal Club presentation (presented by Kenneth Hayworth) on the paper "Synapse-specific representation of the identity of overlapping memory engrams" by Abdou et al. published in the journal Science on June 15th 2018. Here is a link to the paper: http://science.sciencemag.org/content/360/6394/1227 This video presents the results of the paper and discusses the following concepts: 1. Auditory Fear Conditioning in mice 2. Fear memory encoding in the amygdala 2. c-fos::tTA mice 3. Memory engram tagging using immediate early genes 4. Memory reconsolidation and erasure 5. Optogenetic reactivation of a memory 6. Long-term potentiation (LTP) of synapses
This video gives a brief introduction to the concept of using Aldehyde-Stabilized Cryopreservation (ASC) as a last resort medical intervention for terminal patients. ASC requires vascular perfusion of a deadly chemical fixative, so of course its application would immediately terminate the patient’s biological functioning. But it does so in a way that simultaneously preserves the nano-scale structure of the brain. This allows the patient’s brain to be stored, without decay, indefinitely. A terminal patient that chooses ASC is electing to pause their current life in the hope that decades or centuries from now technology will have advanced sufficiently to revive them in a healthy form –most likely through some type of brain scanning and mind uploading. In this video neuroscientist and Brain Preservation Foundation president Kenneth Hayworth argues that ASC should be developed into a reliable medical procedure and offered as a choice to terminal patients. But it is important to s
The Small Mammal Brain Preservation Prize has officially been won by researchers at 21st Century Medicine. Kennith discusses how it was won, it's significance, and where to in the future for brain preservation - he also criticizes the standards of existing Cryonics businesses and how that might effect the credibility of Cryonics as an idea within the wider scientific establishment. http://www.brainpreservation.org/small-mammal-announcement - What to your mind what counts as good baselines of brain preservation? - What baselines should be expected of organisations that sell/provide cryonics services? - Should cryonics organisations be legally accountable to these standards? - Is there potential risk that cryonics orgs with low standards for brain preservation influence the credibility of cryonics as an idea? Quite controversially Ken Hayworth removed himself from Alcor membership - he has said that "I started the Brain Preservation Prize as a challenge to Alcor and other such comp
Dr. Ken Hayworth - Connectomics Pioneer Founding president of the Brain Preservation Foundation. Senior scientist, Howard Hughes Medical Institute's Janelia Farm Research Campus. http://brainpreservation.org/ http://www.janelia.org/people/scientist/kenneth-hayworth Neuroscientists today can preserve small volumes of animal brain tissue immediately after death with incredible precision -- the features and structure of every synapse within these volumes is well-protected down to the nanometer scale, using an inexpensive, room-temperature process of chemical fixation and plastic embedding, or "plastination." The image to the right is an example of plastination and local circuit tracing, occurring in leading neuroscience labs around the world today. This work immediately raises the question: "Can the standard chemical fixation and plastic embedding technique used for electron microscopic investigation of brain circuitry be adapted to preserve the synaptic connectivity of an entire hum
Dr. Ken Hayworth - Connectomics Pioneer Founding president of the Brain Preservation Foundation. Senior scientist, Howard Hughes Medical Institute's Janelia Farm Research Campus. http://brainpreservation.org/ http://www.janelia.org/people/scientist/kenneth-hayworth Neuroscientists today can preserve small volumes of animal brain tissue immediately after death with incredible precision -- the features and structure of every synapse within these volumes is well-protected down to the nanometer scale, using an inexpensive, room-temperature process of chemical fixation and plastic embedding, or "plastination." The image to the right is an example of plastination and local circuit tracing, occurring in leading neuroscience labs around the world today. This work immediately raises the question: "Can the standard chemical fixation and plastic embedding technique used for electron microscopic investigation of brain circuitry be adapted to preserve the synaptic connectivity of an entire hu
Dr. Ken Hayworth - Connectomics Pioneer - http://gf2045.com Founding president of the Brain Preservation Foundation. Senior scientist, Howard Hughes Medical Institute's Janelia Farm Research Campus. http://www.janelia.org/people/scientist/kenneth-hayworth 201305-26 15-58-44
http://www.singularityweblog.com/ken-hayworth-on-chemical-brain-preservation/ Ken Hayworth is the president of the Brain Preservation Foundation and a strong proponent of chemical brain preservation. During my Singularity 1 on 1 interview with Ken we talk about a variety of topics such as: his background in electron-microscopy and how he got interested in it; the motivation behind his work; his skepticism towards curing ageing and mind uploading; his optimism for suspended animation in general and chemical brain preservation in particular; his interesting article Killed By Bad Philosophy; the procedure for chemical brain preservation and the differences to cryonics... My favorite quotes from Hayworth is: "Brain preservation is the logical lifeboat that people have access to today." "Our grandparents had the technology to preserve the precise neural circuitry of their brains for long‐term storage. The best science of our grandparent's era stated unequivocally that this unique patte
Brain Preservation Foundation - Cryonics Wiki Jump to content Main menu Main menu move to sidebar hide Navigation Main page Recent changes Random page Help about MediaWiki Special pages Cryonics Wiki Search Search Appearance Create account Log in Personal tools Create account Log in Pages for logged out editors learn more Contributions Talk Contents move to sidebar hide Beginning 1 Sources 2 External links Toggle the table of contents Brain Preservation Foundation Page Discussion English Read Edit View history Tools Tools move to sidebar hide Actions Read Edit View history Purge General What l … bruary 9, 2016, 21st Century Medicine won BPF's Small Mammal Brain Preservation Prize. [ 2 ] [ 6 ] On March 13, 2018, 21CM won the Large Mammal Brain Preservation Prize. [ 1 ] [ 7 ] Aldehyde-stabilized cryopreservation (ASC) was used in both cases. As of 2018, BPF does not currently support the offering of ASC, or any other preservation method, to human patients. [ 1 ] Sources [ edit ] ↑ 1.0 1.1 1.2 LARGE MAMMAL BPF PRIZE WINNING ANNOUN … F PRIZE WINNING ANNOUNCEMENT . brainpreservation.org ↑ 2.0 2.1 SMALL MAMMAL BPF PRIZE WINNING ANNOUNCEMENT . brainpreservation.org ↑ Thank You for Your Support . brainpreservation.org ↑ YouTube: The case for brain preservation, with Kenneth Hayworth . March 30, 2024. Retrieved April 27, 2026 ↑ Staff . brainpreservation.org. Retrieved April 27, 2026 ↑ Mammal brain frozen and thawed out perfectly for first time . Helen Thomson. New Scientist . February 11, 2016 ↑ New Brain Pres
Mikula Evaluation Page – The Brain Preservation Foundation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FAQ How You Can Help Contact People Advisors Competitors Judges Fellows Staff Volunteers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation About Mission Vision (Preservation Rights) V … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Evaluation of Shawn Mikula’s whole mouse brain entry Dr. Shawn Mikula is a neuroscientist currently at the Max Planck Institute of Neurobiol … 015 issue. Dr. Mikula has been an official competitor in our Brain Preservation Prize competition since 2012. In that time he has sent us many electron micrographs of his whole mouse brain tests demonstrating promising results. On three separate occasions in the past, Dr. Mikula has provided the BPF with a mouse brain for official evaluation, however on both of those occasions we found damage sufficient to reject the entry. The first brain we imaged showed large cortical crac … to us as an official entry in the small mammal phase of our Brain Preservation Prize competition. The chemical used to preserve the lipid membranes of cells (osmium tetroxide) darkens the tissue to deep black in color which is why the brain looks so dark in its plastic block. As a preliminary check of quality we performed an X-ray micro CT scan on the brain with a voxel resolution of 16 microns. The results of our X-ray volume imaging are shown below. Aside from minor dissec … t be Difficult to Discuss or Adopt Do We Need a Noncryogenic Brain Preservation Prize? The Personal and Social Value of Brain Preservation – One View: A Response to Sue Blackmore’s Guardian Article Categories Brain Preservation Mind Uploading Interviews Cryopreservation Electron Microscopy Macular Degeneration Cryonics Survey Chemopreservat
Competitors – The Brain Preservation Foundation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FAQ How You Can Help Contact People Advisors Competitors Judges Fellows Staff Volunteers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation About Mission Vision (Preservation Rights) Value (Overc … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Competitors Shawn Mikula, Winfried Denk Lab Dr. Mikula is a post-doctoral researcher at the Max Planck Institute for Medical Research in Heidelber … la, Helmstaedter, and Denk 2011 ]. As part of the Brain Preservation Technology Prize competition, Dr. Mikula has agreed to demonstrate the quality of ultrastructure preservation which his protocol can achieve. Below are sample optical and electron micrographs he has provided as an example of his preservation procedure. He has recently posted an SEM montage of a full coronal slice through one of his preserved mouse brains at a resolution of 80nm. 21st Century Medicine 21st Ce … e process to such organs. However, as part of the Brain Preservation Technology Prize competition, they have agreed to demonstrate the quality of ultrastructure preservation that their low temperature vitrification technique can achieve when applied to whole rabbit brains. Below is a sample electron micrograph which 21st Century Medicine has provided us as an example of their preservation procedure: Contact For general inquiries, collaboration, or gift-giving questions, pleas … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Start typing a
Shawn Mikula on Brain Preservation Protocols and Extensions – The Brain Preservation Foundation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FAQ How You Can Help Contact People Advisors Competitors Judges Fellows Staff Volunteers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation About M … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Shawn Mikula on Brain Preservation Protocols and Extensions By Admin Posted April 27, 2015 In Electron Microscopy Shawn Mikula … t be Difficult to Discuss or Adopt Do We Need a Noncryogenic Brain Preservation Prize? Leave a Comment Cancel reply Save my name, email, and website in this browser for the next time I comment. Δ Contact For general inquiries, collaboration, or gift-giving questions, please contact: [email protected] Disclaimer Several companies now offer brain preservation services (aka biostasis) for human patients. The biostasis industry is presently quite young, with seve … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Start typing and press Enter to search Peter Gouras on Fixation Methods and Human Brain Preservation Electron Microscopy, Macular Degeneration
Lifeboat Foundation Bios: Dr. Shawn Mikula Skip to content Lifeboat Foundation: Safeguarding Humanity About Blog Boards Programs Reports Papers Donate Join Us Newsletter Quotes Store Press Releases Toggle sitemap Lifeboat Foundation Sitemap icon-search Main Areas Home About Boards Blog Programs Reports Papers Donate Join Us Newsletter Quotes Store Press Releases Current Programs AIShield AsteroidShield BioShield InfoPreserver InternetShield LifePreserver LifeShield Bunkers NanoShield ScientificFreedomShield SecurityPreserver Space Habitats X-Risks Network Cool Places A-PRIZE Ark I Blue Beauty … gs Outreach Partnerships Rosetta@Home Volunteer Work About Us Bitcoin Endowment Fund Boards Board of Directors Contact Us Donor List FAQ Finances Guardian Award Interactive Friendly AI Logo Memorial Board Mission Statement Procedures Staff Supplemental FAQ Timeline More Programs AlienShield AntimatterShield BioPreserver BlackHoleShield ClimateShield CommPreserver EnergyPreserver GammaRayShield NeuroethicsShield NuclearShield ParticleAcceleratorShield PersonalityPreserver Seed … hored Internet-Enabled High-Resolution Brain Mapping and Virtual Microscopy , A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale , The Effects of Input Rate and Synchrony on a Coincidence Detector: Analytical Solution , Complete 3-D visualization of primate striosomes by KChIP1 immunostaining , Interactive Visualization of Multiresolution Image Stacks in 3D , and A novel method for visua … pdate from Competitors for the Brain Preservation Foundation’s Technology Prize . View his Facebook page . Read his Google+ profile and his LinkedIn profile . Follow his X feed . Death The Lifeboat Foundation mourns Shawn’s passing in Tokyo where he had been working at Keio University School of Medicine. GETAS Threat Level ELEVATED FACEBOOK: 16,180 MEMBERS LIFEBOAT NEWS: 3,449 SUBSCRIBERS LINKEDIN: 7,082 MEMBERS GETAS ALERTS: 895 SUBSCRIBERS X FEED: 31,261 MEMBERS
Brain Preservation Foundation Prize Update – Fight Aging! Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging! Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. The sooner these treatments arrive, the more lives will be saved. Find out how to help » May 26th, 2015 Brain Preservation Fou … aved. Find out how to help » May 26th, 2015 Brain Preservation Foundation Prize Update Permalink (With Comments) Permalink (No Comments) Posted by Reason Read 1 Comment Add a Comment The Brain Preservation Foundation aims at advancing and validating the state of the art for preserving the fine structure of the human brain, containing the data of the mind. This is a goal of great value for the cryonics industry, and for the possible plastination industry that might arise … is worth trying to change. The Brain Preservation Foundation runs a technology prize to help accelerate and publicize progress in preservation technologies. Here is a recent update on the current batch of competitors: Brain Preservation Prize competitor Shawn Mikula has just published the first ever paper demonstrating how an entire mouse brain can be preserved at the ultrastructure level for electron microscopic (EM) imaging of its entire connectome . As is well known to al … results sufficient for Mikula to win the mouse phase of our Brain Preservation Prize? The short answer is yes - if the claims made in the paper can be verified by our imaging then Mikula will be awarded the mouse phase of our prize. Another key question is whether his 'formamide' technique will be able to be scaled up to a large mammal - like the pig brain required for the final phase of our prize, or a human brain? Dr. Mikula is already working to procure high-quality gluta … e rabbit brains that 21CM has perfused with cryoprotectant agents (CPA) for our prize have shown significant amounts of shrinkage due to dehydration from the high concentration and fast ramping of CPA used. Electron micrographs of this tissue are thus difficult to interpret and we have been unable to accurately assess the degree of ultrastructure
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x This website requires javascript to properly function. Consider activating javascript to get access to all site functionality. LESSWRONG LW Login Update on the Brain Preservation Foundation Prize — LessWrong Cryonics Life Extension Personal Blog 41 Update on the Brain Preservation Foundation Prize by Andy_McKenzie 26th May 2015 1 min read 6 41 Brain Preservation Foundation President Kenneth Hayworth just wrote a synopsis of the recent ongoings from the major two competitors for the BPF prizes. Here is the summary: Brain Preservation Prize competitor Shawn Mikula just published his whole mous … ( paper , BPF interview ), putting him close to winning the mouse phase of our prize. Brain Preservation Prize competitor 21st Century Medicine has developed a new “Aldehyde-Stabilized Cryopreservation” technique–preliminary results show good ultrastructure preservation even after storage of a whole rabbit brain at -135 degrees C. This work was funded in part from donations from LW users. In particular, a grant to support the work of LW user Robert McIntyre at 21st Century M … discuss them in the comments below. Update on the Brain Preservation Foundation Prize 11 Adam Zerner 33 Andy_McKenzie 6 gwern 6 Andy_McKenzie 1 AndreInfante 0 Andy_McKenzie 6 Comments 6 Cryonics Life Extension Personal Blog 41 New Comment Submit 6 comments , sorted by top scoring Click to highlight new comments since: Today at 6:06 AM [ - ] Adam Zerner 11y 11 0 Would you mind summarizing the summary? :) I'm not familiar with the science but would like to understand the g … Mentioned in 71 The Brain Preservation Foundation's Small Mammalian Brain Prize won
About – Aspirational Neuroscience Skip to content Journal Club Journal Club – Next Meeting Join the JC SfN Meetup 2025 Quotes Nominations Nominate Nominate Awards About X Welcome Neuroscientists The Aspirational Neuroscience (AN) community is currently run by neuroscientist Kenneth Hayworth ( [email protected] , @KennethHayworth ), Janelia Research scientist and President of the Brain Preservation Foundation , along with a handful of other neuroscientists. If you are a student or professional neuroscientist, other scientist, or technical practitioner interested in th
Brain Preservation Foundation - Wikipedia Jump to content Main menu Main menu move to sidebar hide Navigation Main page Contents Current events Random article About Wikipedia Contact us Contribute Help Learn to edit Community portal Recent changes Upload file Special pages Search Search Appearance Donate Create account Log in Personal tools Donate Create account Log in Contents move to sidebar hide (Top) 1 Prizes 2 See also 3 References Toggle the table of contents Brain Preservation Foundation 1 language Français Edit links Article Talk English Read Edit View history Tools Tools move to sideb … izes [ edit ] In 2010, the Brain Preservation Foundation launched an inducement prize contest with the goal of improving the long-run preservation of human brains. The purpose of preserving a human brain is to allow the mind uploading of the preserved brain's long-term memories if the technology becomes available to do so in the long-run future. [ 4 ] The requirements of the Brain Preservation Technology Prize stated that the connectome of a brain had to be preserved … years). [ 5 ] On February 9, 2016, the Small Mammal Brain Preservation Prize was officially won by the cryobiology research company 21st Century Medicine . [ 6 ] On March 13, 2018, the Large Mammal Brain Preservation Prize was officially won, again by 21st Century Medicine. [ 7 ] See also [ edit ] Cryonics 21st Century Medicine Information-theoretic death References [ edit ] ^ a b "Donors – The Brain Preservation Foundation" . 16 September 2015 . Retr … "Is An Identical Copy Of You, You?" . NPR.org . Retrieved 2019-01-25 . ^ "Tech Prize – The Brain Preservation Foundation" . 16 September 2015 . Retrieved 2018-12-23 . ^ Shermer, Michael (2016-02-01). "Can Our Minds Live Forever?" . Scientific American . Archived from the original on 2018-11-25 . Retrieved 2018-12-23 . ^ Blackmore, Sue (2018-03-14). "Brain preservation is a step closer, but how could it ever be 'you'? | Sue Blackmore" . The Guardian . ISSN   0261-3077 . … the Creative Commons Attribution-ShareAlike 4.0 License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy . Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. , a non-profit organization. Privacy policy About Wikipedia Disclaimers Contact Wikipedia Legal & safety contacts C
Kenneth Hayworth – The Brain Preservation Foundation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FAQ How You Can Help Contact People Advisors Competitors Judges Fellows Staff Volunteers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation About Mission Vision (Preservation Rights) Value ( … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Kenneth Hayworth President and Co-Founder of the Brain Preservation Foundation Kenneth Hayworth, President and Co-Founder of the Brain Preservatio … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Start typing and press Enter to search John Smart Ben Scarlato
Carboncopies.org Foundation - GF2045(2013) Proceedings: Dr. Ken Hayworth Search this site Embedded Files Skip to main content Skip to navigation Carboncopies.org Foundation Home carboncopies Gear 2014 Conference of the Mormon Transhumanist Association A Window of Opportunity About Frequently Asked Questions You want to help, but you don't know where to start? AGI-11 Conference, Mountain View, 3-7 August, 2011 AGI-11 Call for Neuroscience Papers ASIM 2010 Conference, San Francisco, August 16-17th ASIM Experts Series: Brain-machine interfacing: current work and future directions, by Max Hoda … Issue on Mind Uploading Implications of the BPF small mammal brain preservation prize, from the prosaic to the profound Intelligence Unbound: The Future of Uploaded and Machine Minds JAGI Special Issue on Brain Emulation and Connectomics, a convergence of Neuroscience and Artificial General Intelligence (Dec 2013) Join Carboncopies.org! LASER USF talk: Why and how to transition from wet-ware to substrate-independent minds, by Randal A. Koene, 12 September, 2011 NERVE 2013: Di … ion Foundation a few years ago, and that's why we've issued a challenge prize to all scientists and medical researchers to develop such a brain preservation technique. Once this prize is one and quality brain preservation start being offered in regulated hospitals worldwide, the real mind uploading revolution will have begun. Content Next: Dr. Amit Goswami -- Consciousness and the Quantum: Science, Psychology and Spirituality Previous: Dr. Randal A. Koene -- Whole Bra
Carboncopies.org Foundation - Implications of the BPF small mammal brain preservation prize, from the prosaic to the profound Search this site Embedded Files Skip to main content Skip to navigation Carboncopies.org Foundation Home carboncopies Gear 2014 Conference of the Mormon Transhumanist Association A Window of Opportunity About Frequently Asked Questions You want to help, but you don't know where to start? AGI-11 Conference, Mountain View, 3-7 August, 2011 AGI-11 Call for Neuroscience Papers ASIM 2010 Conference, San Francisco, August 16-17th ASIM Experts Series: Brain-machine interfa … Issue on Mind Uploading Implications of the BPF small mammal brain preservation prize, from the prosaic to the profound Intelligence Unbound: The Future of Uploaded and Machine Minds JAGI Special Issue on Brain Emulation and Connectomics, a convergence of Neuroscience and Artificial General Intelligence (Dec 2013) Join Carboncopies.org! LASER USF talk: Why and how to transition from wet-ware to substrate-independent minds, by Randal A. Koene, 12 September, 2011 NERVE 2013: Di … oncopies.org Foundation Implications of the BPF small mammal brain preservation prize, from the prosaic to the profound Implications of the BPF small mammal brain preservation prize, from the prosaic to the profound Keith Wiley Author of A Taxonomy and Metaphysics of Mind-Uploading Brain Preservation Foundation fellow Feb. 10, 2016 On February ninth, the Brain Preservation Foundation (BPF) announced the winner of its small mammal prize for the successful preservation of a rab … of serving as an advisor to the BPF, whose primary purpose has been to manage a prize similar to “X prizes” for other technological innovations, this one in the area of brain preservation techniques (which notably requires peer-reviewed publication of the contributing work so as to vet the success in the broader research community). We have anticipated for many months (longer in fact) that a win was imminent from one of two candidate techniques, a cryogenic method pioneered b … could come to fruition at nearly the same time. Although one officially won the prize, we can take this close timing as an indication that there will soon be not one, but two notably diverse options available for the long term preservation of brains. This diversity is, of course, good news since each method may offer advantages over the other for
Your Future Self Will Thank Yo… — Neurotech Pub — Apple Podcasts Buscar Início Novidades Top charts Buscar 22 de março de 2023 1h 1min Your Future Self Will Thank You | Connectomics Part II Neurotech Pub Reproduzir We’re back with Part II of our two-part series on Connectomics! In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine
Connectomics Part I: We're in Heated Agreement Over Here | Neurotech Pub Platform Platform Current & Future Applications Connexus ® current product Brain-Computer Interface Tempo TM current product Pipeline Product Company News & Insights Careers Clinical Study Platform Platform Current & Future Applications Connexus ® current product Brain-Computer Interface Tempo TM current product Pipeline Product Company News & Insights Careers Clinical Study Connectomics Part I: We’re in Heated Agreement Over Here Mar 15, 2023 --> --> Or listen here on Apple Podcasts . In this first installment … 3 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize 3:56 | The Brain Preservation Foundation 4:09 | Documentary series on the Brain Preservation Foundation 5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats) 5:51 | Nita’s 2018 Neuroethics Ted Talk 5:54 | International Neuroethics Society 6:25 | Connectomics & new paths in neuroscience 8:10 | Allen Institute for Brain Science 8:47 | A connecto
Ken Hayworth: Brain Preservation is the Logical Lifeboat Skip to main content Skip to primary sidebar About Blog Book Podcast Speaker Contact About Blog Book Podcast Speaker Contact Ken Hayworth: Brain Preservation is the Logical Lifeboat Nikola Danaylov / Podcasts Posted on: January 16, 2013 / Last Modified: June 20, 2024 https://media.blubrry.com/singularity/feeds.soundcloud.com/stream/198572067-singularity1on1-ken-hayworth.mp3 Podcast: Play in new window | Download | Embed Subscribe: RSS Ken Hayworth is the president of the Brain Preservation Foundation and a strong proponent of chemical br … brain preservation and mind uploading and, through the BPF’s Brain Preservation Prize, he has challenged scientists and medical researchers to develop a reliable, scientifically verified surgical procedure that can demonstrate long-term ultrastructure preservation across an entire human brain. Once won, Hayworth advocates for the widespread implementation of such a surgical procedure in hospitals. Several research labs are currently attempting to win this prize. Related artic
Alcor Position Statement on Brain Preservation Foundation Prize - Alcor Life Extension Foundation Donate Member Portal Contact Us Emergency Contact Us EN FR About Us About Us The Alcor Advantage Meet the Team Cryonics Intro to Cryonics Deployment & Recovery Cryopreservation Procedures Research & Development Membership Membership Overview Pricing & Dues Provider Comparison My Member Portal International Membership Alcor Canada Alcor Europe Pets Pet Cryopreservation Get Connected Alcor Newsletter The Alcor Podcast Social Media Career Opportunities Resources Recent News FAQs Press Kit … Donate Member Portal Alcor Position Statement on Brain Preservation Foundation Prize From Alcor President, Max More March 13, 2018 In December 2015, 21st Century Medicine, Inc. published peer-reviewed results of a new cryobiological and neurobiological technique, aldehyde-stabilized cryopreservation (ASC) that provides strong proof that brains can be preserved well enough at cryogenic temperatures for neural connectivity (the connectome) to be completely visualized. This wee … Ken Hayworth, President of the BPF, awarded The Large Mammal Brain Preservation Prize to 21st Century Medicine based on these results. In 2016 the company had been previously awarded the Small Mammal Brain Preservation Prize for work using the same technology. Many people are wondering whether Alcor plans to adopt the “Aldehyde-Stabilized Cryopreservation” (ASC) protocol used to win the prize and what the win means for cryonics in practice. Alcor’s position is as follows: We … d ASC and has now won both the Small Mammal and Large Mammal Brain Preservation Prize. ASC under the name “fixation and vitrification” was first proposed for cryonics use in 1986 . ASC enables excellent visualization of cellular structure – which was the objective that had to be met to win the prizes – and shows that brains can be preserved well enough at low temperature for neural connectivity to be shown to be preserved. Current brain vitrification methods without fixation … in utilizing blood-brain barrier opening technology such as was used to win the prize. It may remain unclear to some whether this research and associated prizes show whether ASC or current vitrification without pre-fixation is more likely to preserve cell structures and molecular structures necessary for memory and personal identity. What we can
Standards/Accreditation – The Brain Preservation Foundation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FAQ How You Can Help Contact People Advisors Competitors Judges Fellows Staff Volunteers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation About Mission Vision (Preservation Rights) … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation Standards/Accreditation Home / Standards/Accreditation Setting standards for brain preservation quality Monitoring preservation’s transition f … scientific foundation, in 2010 the Brain Preservation Foundation established a prize for the first team to rigorously demonstrate a technique capable of preserving an entire brain for long-term storage with such fidelity that “the structure of every neuronal process and every synaptic connection remains intact and traceable using today’s electron microscopic imaging techniques.” While additional factors beyond traceability – such as specific receptor types, … des an evidence-based minimum standard for preservation quality assessment. The prize was eventually won in 2018 with the development of aldehyde-stabilized cryopreservation (ASC), with rigorous assessment showing that it could meet this concrete benchmark for preservation quality. A) FIBSEM electron micrograph taken of a section of pig cortex preserved using aldehyde-stabilised cryopreservation. Taken as part of the BPF’s ASC Evaluation images. B) Transmission electron micro … requires robust quality standards and oversight mechanisms to ensure consistent application and continuous improvement by preservation providers. The Brain Preservation Foundation’s mission is to promote validated scientific research and technical services development in the field of whole brain preservation and to advocate for guidelines,
The Brain Preservation Foundation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FAQ How You Can Help Contact People Advisors Competitors Judges Fellows Staff Volunteers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation About Mission Vision (Preservation Rights) Value (Overcoming Objections) FA … eers Donors Newsletter Old Blog (Archives) Newsletter Aspirational Neuroscience Prize Brain Preservation Prize Large Mammal BPF Prize Winning Announcement Prize Overview 21CM Cryo for Viability 21CM Aldehyde-Stabilized Cryo Mikula Mouse Brain Chemo Media Videos BPF in the News Books / Essays / Papers / Links Standards/Accreditation 3 min Explainer Video - The Brain Preservation Option BPF Video Series Episode 1 of 8 – Opening Statement: Our Mission The Brain Preservation Foun … s on How You Can Help . Quick Links to Recent Content Aspirational Neuroscience Prize: Call for Nominations YouTube Video Documentary Series on the Brain Preservation Foundation Episode 1 – Opening Statement Episode 2 – Redefining the Status Quo Episode 3 – Reasonable Scientific Objections Episode 4 – Broader Applicability Episode 5 – Long-Term Arguments Episode 6 – The Social Mission Episode 7 – Preservation Done Right Episode 8 – How Will It Work? Neuroscience of Learning a … se: Aldehyde-Stabilized Cryopreservation Wins Final Phase of Brain Preservation Prize Kenneth Hayworth’s Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats) Vitrifying the Connectomic Self: A case for developing Aldehyde Stabilized Cryopreservation into a medical procedure (Essay) Pig Prize Evaluation Images (3D Electron Microscopy and Gross Dissection Views) Introduction The Great Library of Alexandria , constructed in the third … , and synaptic changes that form the molecular basis of memory. The 2014 Kavli Prize in Neuroscience was won by three neuroscientists for the discovery of specialized brain networks for memory and cognition. The 2016 Brain Prize was won by three neuroscientists for elucidating the molecular mechanisms of long-term potentiation , one of the keys
A startup is pitching a mind-uploading service that is “100 percent fatal” | MIT Technology Review You need to enable JavaScript to view this site. Skip to Content MIT Technology Review Featured Topics Newsletters Events Audio MIT Technology Review Featured Topics Newsletters Events Audio Humans and technology A startup is pitching a mind-uploading service that is “100 percent fatal” Nectome will preserve your brain, but you have to be euthanized first. By Antonio Regalado archive page March 13, 2018 Nectome The startup accelerator Y Combinator is known for supporting audacious companies in it … r way, you should pay attention to Nectome. The company has won a large federal grant and is collaborating with Edward Boyden, a top neuroscientist at MIT, and its technique just claimed an $80,000 science prize for preserving a pig’s brain so well that every synapse inside it could be seen with an electron microscope. McIntyre, a computer scientist, and his cofounder Michael McCanna have been following the tech entrepreneur’s handbook with ghoulish alacrity. “The user experi … he organization that, on March 13, recognized McIntyre and Fahy’s work with the prize for preserving the pig brain. There’s no expectation here that the preserved tissue can be actually brought back to life, as is the hope with Alcor-style cryonics. Instead, the idea is to retrieve information that’s present in the brain’s anatomical layout and molecular details. “If the brain is dead, it’s like your computer is off, but that doesn’t mean the information isn’t there,” says Ha … or provides to all the companies it accepts. It has also won a $960,000 federal grant from the U.S. National Institute of Mental Health for “whole-brain nanoscale preservation and imaging,” the text of which foresees a “commercial opportunity in offering brain preservation” for purposes including drug research. About a third of the grant funds are being spent in the MIT laboratory of Edward Boyden, a well-known neuroscientist. Boyden says he’s seeking to combine McIntyre’s pr