Meditation Retreat Biological and Physiological Data Research Program
exploratoryresearch program · high · Wed Jun 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Study personal change and transformation by collecting personal, biological, and physiological data around meditation retreats and enabling independent multidisciplinary analysis of meditation's effects on human biology and mind-body connection.
Collection of personal, biological, and physiological data from meditation retreat participants, with analysis by multidisciplinary teams and partner researchers including University of California San Diego scientists.
Metamorphosis site states the organization was founded and funded in 2021 to support Dr Joe Dispenza's scientific research and exploration; supplied materials list multiple 2025-2026 publications using retreat-associated biological, physiological, neural, and random-number-generator measurements.
Supplied publications report meditation-associated changes across gene expression, metabolites, cytokines, EEG, heart-rate dynamics, fMRI connectivity, plasma proteomics, metabolomics, exosome miRNA, neurite outgrowth, cellular metabolism, and random-number-generator network coherence.
Mind-Body Reconceptualization, Meditation, and Open-Label Placebo Healing Intervention Study
exploratoryresearch program · high · Thu Nov 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Measure short-term neural and molecular effects of an intensive non-pharmacological mind-body retreat intervention on healthy human participants.
Observational study of 20 randomly selected participants from a 561-person, 7-day retreat using resting and meditation BOLD fMRI functional connectivity, plasma proteomics and metabolomics, exosome-specific miRNA transcriptomics, neurite growth assays, and real-time metabolism cellular assays before and after intervention.
Communications Biology publication on 2025-11-06.
Meditation decreased functional integration in default mode and salience networks and decreased whole-brain modularity; post-intervention plasma increased in vitro neurite outgrowth, enhanced glycolytic metabolism, upregulated BDNF, inflammatory, anti-inflammatory, and endogenous opioid pathways, and modulated tryptophan metabolism and neurotransmission-associated exosome miRNA transcripts.
Mind-Body Reconceptualization, Meditation, and Open-Label Placebo Healing Retreat Study
exploratoryresearch program · medium · Thu Nov 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess short-term neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals.
Observational study of 20 healthy participants randomly selected from 561 retreat participants, comparing pre- and post-intervention BOLD fMRI functional connectivity during rest and meditation, plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, neurite-growth assays, and real-time metabolism cellular assays.
Published in Communications Biology on 2025-11-06.
Reported decreased functional integration in default-mode and salience networks, decreased whole-brain modularity, increased in vitro neurite outgrowth, enhanced glycolytic metabolism, BDNF upregulation, inflammatory and anti-inflammatory pathway modulation, endogenous opioid pathway modulation, tryptophan metabolism modulation, and neurotransmission-associated exosome miRNA changes.
Global and Local Random Number Generator Coherence During Group Healing Meditations
exploratoryresearch program · high
Investigate whether focused group healing meditations are associated with measurable coherent activity in local and global random number generator networks.
Exploratory analysis of a local tower of 40 RNGs placed in meditation rooms during Joe Dispenza meditation workshops, compared with hundreds of globally distributed RNGs; Network Coherence was analyzed during 15 healing meditations.
2025 EXPLORE publication reporting significant local-global Network Coherence correlations during healing meditations.
During 15 healing meditations, mean correlation between global and local Network Coherence was 0.27 with p < 0.01; combined local RNG coherence produced a distinctive curve resembling an evoked response.
Global and Local Random Number Generator Network Coherence Meditation Study
exploratoryresearch program · high
Investigate whether group healing meditations correlate with coherent behavior in local and global random-number-generator networks.
Exploratory analysis of meditation workshops led by Dr Joe Dispenza with 1000-2200 participants, using a local tower of 40 RNGs in the meditation room and hundreds of distributed global RNGs. Local and global outputs were processed for randomness and analyzed for Network Coherence during 15 Coherence Healing meditations.
Publication in Explore in 2026 covering events from the first half of 2024.
During healing meditations, the study reported a significant mean correlation of 0.27 between local and global Network Coherence values, p < 0.01. Combined local RNG Network Coherence across healing periods produced a curve described as resembling an evoked response.
Global Coherence Random Number Generator Meditation Study
exploratoryresearch program · medium
Investigate whether focused group meditation or coherence healing sessions correlate with coherent activity in local and global random number generator networks.
A local tower of 40 RNG devices was placed in meditation rooms during Dr Joe Dispenza workshops and compared with hundreds of globally distributed RNGs; network coherence was analyzed during healing meditation periods.
2026 publication reported correlations between onsite and global RNG networks during group healing meditations from events in the first half of 2024.
During 15 healing meditations, local and global Network Coherence showed a mean correlation of 0.27 with p < 0.01; combined local RNG coherence produced a curve resembling an evoked response.
Global Consciousness Project 2.0 Group Healing Meditation RNG Network Study
exploratoryresearch program · high
Investigate whether group healing meditations correlate with measurable coherence patterns in onsite and globally distributed random number generator networks.
Exploratory analysis of meditation workshops led by Dr Joe Dispenza with 1000-2200 participants, comparing a local tower of 40 RNG devices in the meditation room with hundreds of globally distributed RNGs using Network Coherence during Coherence Healing meditations.
Published 2026 study in Explore analyzing events from the first half of 2024.
Reported significant correlation between global and local RNG Network Coherence during 15 healing meditations, with mean correlation 0.27 and p < 0.01; combined local RNG coherence produced a distinctive curve described as resembling an evoked response.
Group Healing Meditation Random Number Generator Coherence Study
exploratoryresearch program · high
Investigate whether group healing meditations are associated with coherent activity in local and global random number generator networks.
Exploratory analysis of a local tower of 40 random number generators placed in meditation rooms during Joe Dispenza workshops, compared with hundreds of globally distributed random number generators using Network Coherence measures during healing meditations.
2025 EXPLORE publication reporting correlations between onsite and global random number generator networks during group healing meditations.
Across 15 healing meditations, local and global Network Coherence showed a significant mean correlation of 0.27 with p < 0.01, observed during healing meditations but not at other times; combined local Network Coherence produced a curve resembling an evoked response.
InnerScience Research Fund Meditation Research Funding Program
undisclosedother · medium
Fund research on biological and physiological effects of meditation on the human body and support data analysis for Metamorphosis-linked research.
Nonprofit research funding and donor program, including donations through InnerScience Research Fund and support for Dr Hemal Patel's UC San Diego Foundation fund.
InnerScience Research Fund public pages describe an active 501(c)(3) donor program and monthly donor community supporting meditation research.
Intensive Week-Long Meditation Retreat Twin Pilot Study
exploratoryresearch program · high
Evaluate biological, neural, biometric, and molecular effects of meditation while controlling for genetic background using twin sets.
Pilot study of twins during a week-long meditation retreat using whole-blood transcriptomics, plasma metabolomics, biochemical assays, quantitative EEG, biometric analysis, and heart-rate dynamics at multiple time points.
Published 2025 pilot study in Mindfulness under IRB protocol MED02#20211477.
Reported meditation-associated changes in gene expression, metabolites, cytokines, EEG spectral power correlations among twin pairs, and heart-rate dynamics alignment among twin pairs, with no comparable alignment in mismatched pairs.
Meditation Biology Data Collection Research Program
exploratoryresearch program · high
Study the effects of meditation and personal transformation on human biology, physiology, and the mind-body connection.
Collection of personal, biological, and physiological data and original biological material at retreats around the world, with data and samples entrusted to partner researchers including UC San Diego scientists.
Ongoing retreat-based data collection and partner research support described by Metamorphosis.
Meditation Effects on Human Biology Research Program
exploratoryresearch program · high
Study personal change and transformation by measuring biological, physiological, personal, and environmental data from meditation retreat participants, with materials and data entrusted to partner researchers for independent analysis.
Collection of biological, physiological, personal, and environmental data from retreat participants; independent analysis by partner institutions including University of California San Diego.
Metamorphosis site states the program was founded and funded in 2021 to support Dr Joe Dispenza's scientific research and exploration, with donation support directed to the Inner Science Research Fund or Dr Hemal Patel's UC San Diego Foundation fund.
Metamorphosis Biological and Physiological Meditation Data Collection Program
exploratoryplatform · high
Capture personal, biological, and physiological data to study the effects of meditation on human biology and the mind-body connection.
Ongoing collection of personal, biological, and physiological data at retreats around the world, with original biological material and data entrusted to partner researchers including scientists at University of California San Diego.
Metamorphosis stated that Dr Joe Dispenza founded and funded the organization in 2021 to support scientific research and exploration, and that donations can support data analysis through the Inner Science Research Fund or Dr Hemal Patel’s UC San Diego Foundation fund.
Metamorphosis Meditation Biology Research Program
exploratoryresearch program · high
Study how meditation and mind-body retreat practices affect human biology, physiology, personal state, environmental measures, and broader coherence signals.
Collection of biological, physiological, personal, and environmental data from retreat participants, with materials and data entrusted to partner researchers including UC San Diego for independent analysis.
Metamorphosis was founded and funded in 2021 to support Dr Joe Dispenza's scientific research and exploration; site material states donations can support data analysis through the Inner Science Research Fund or Dr Hemal Patel's UC San Diego Foundation fund.
Mind-Body Retreat Neural and Molecular Effects Study
exploratoryresearch program · medium
Characterize short-term neural and plasma-based molecular effects of an intensive mind-body retreat intervention.
Observational study of 20 healthy participants randomly selected from 561 retreat participants, comparing pre- and post-intervention resting and meditation fMRI, plasma proteomics, metabolomics, exosome miRNA transcriptomics, neurite growth assays, and real-time metabolism cellular assays.
2025 publication in Communications Biology reporting neural and molecular changes after the retreat intervention.
The intervention was associated with decreased default-mode and salience-network functional integration, decreased whole-brain modularity, increased in vitro neurite outgrowth, enhanced glycolytic metabolism, BDNF upregulation, inflammatory and anti-inflammatory pathway modulation, endogenous opioid pathway modulation, and changes in tryptophan metabolism and neurotransmission-associated exosome miRNA transcripts.
Mind-Body Retreat Neural and Molecular Profiling Study
exploratoryresearch program · medium
Characterize neural and molecular effects of a 7-day mind-body retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals.
Observational study of 20 healthy participants randomly selected from 561 retreat participants; compared pre- and post-intervention BOLD fMRI, plasma proteomics, metabolomics, exosome miRNA transcriptomics, neurite growth assays, and real-time cellular metabolism assays.
2025 publication in Communications Biology.
Reported decreased functional integration in default mode and salience networks, decreased whole-brain modularity, increased in vitro neurite outgrowth, enhanced glycolytic metabolism, BDNF pathway upregulation, inflammatory and anti-inflammatory pathway modulation, endogenous opioid pathway modulation, tryptophan metabolism changes, and neurotransmission-associated exosome miRNA transcript changes.
Twin Meditation Retreat Multi-Omics and Biometric Pilot Study
exploratoryresearch program · high
Explore the biological, physiological, and neural effects of a week-long meditation retreat in twin sets while controlling for genetic background and intersubject trait variation.
Pilot twin cohort study during a week-long meditation retreat using whole-blood transcriptomics, plasma metabolomics, biochemical and cytokine assays, quantitative EEG, biometric analysis, and heart-rate dynamics across multiple time points.
2025 Mindfulness publication of pilot study under IRB protocol MED02#20211477.
Twin sets showed changes in gene expression, metabolites, and cytokines associated with meditative states; twins diverged at mid-retreat and became more similar by the end; spectral power and heart-rate dynamics correlations were observed among twin pairs but not mismatched pairs.
Twin Meditation Retreat Multi-Omics Pilot Study
exploratoryresearch program · medium
Investigate the impact of mind-body interventions on biological, biometric, and neural measures in twins during a week-long meditation retreat, including the role of shared genetic background.
Pilot study of twin sets during an intensive week-long meditation retreat using whole-blood transcriptomics, plasma metabolomics and biochemical assays, cytokine measurements, quantitative EEG, biometric analysis, and heart-rate dynamics at multiple time points, including twins meditating together or separated.
Publication in Mindfulness in 2025; study conducted under IRB protocol MED02#20211477 and not preregistered.
Reported timepoint-associated changes in gene expression, metabolites, and cytokines; twin sets were similar before retreat, diverged at midpoint, and became more similar by retreat end. Twin pairs also showed spectral-power correlations in separate rooms and heart-rate alignment not observed in mismatched pairs.
